| Gene Symbol |
CEP55
|
| Entrez Gene |
55165
|
| Alt Symbol |
C10orf3, CT111, URCC6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centrosomal protein 55kDa
|
| Other Description |
cancer/testis antigen 111|centrosomal protein of 55 kDa|up-regulated in colon cancer 6
|
| Swissprots |
B2RDG8 Q3MV20 Q53EZ4 Q96H32 Q9NVS7 Q6N034 Q32WF5 Q5VY28
|
| Accessions |
CAJ29952 CAN87445 CAN87446 CAN87449 CAN87453 EAW50071 EAW50072 Q53EZ4 AB091343 BAE45243 AK001402 BAA91670 AK223495 BAD97215 AK315536 BAG37915 AY788918 AAX14687 BC008947 AAH08947 BX640718 CAE45837 DA545074 HQ447335 ADQ31821 XM_011539918 XP_011538220 XM_011539919 XP_011538221 XM_011539920 XP_011538222 NM_001127182 NP_001120654 NM_018131 NP_060601
|
| Function |
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.
|
| Tissue Specificity |
Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16406728}.
|
