| Gene Symbol |
ARHGEF26
|
| Entrez Gene |
26084
|
| Alt Symbol |
CSGEF, HMFN1864, SGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 26
|
| Other Description |
SH3 domain-containing guanine exchange factor|Src homology 3 domain-containing guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 26
|
| Swissprots |
Q9H9R2 Q9UFW5 Q6Q8Q8 E9PBD0 Q96DR6 B3KVP8 Q96AW8 Q96DR7 Q68CL1 Q9H9D7 Q6AZ96
|
| Accessions |
EAW78764 Q96DR7 AB073386 BAD38637 AF415175 AAL27001 AF415176 AAL27002 AK022655 BAB14159 AK022884 BAB14292 AK123040 BAG53860 AK127282 BAG54472 AL117429 CAB55918 AY552599 AAS59842 BC016628 AAH16628 BC078655 AAH78655 DA248533 DB069290 XM_011512672 XP_011510974 XM_011546470 XP_011544772 NM_001251962 NP_001238891 NM_001251963 NP_001238892 NM_015595 NP_056410
|
| Function |
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
|
| Subcellular Location |
Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}.
|
| Tissue Specificity |
Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269|PubMed:12697679, ECO:0000269|PubMed:15133129}.
|
| Top Pathways |
Bacterial invasion of epithelial cells
|