ARHGEF26

Gene Symbol ARHGEF26
Entrez Gene 26084
Alt Symbol CSGEF, HMFN1864, SGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 26
Other Description SH3 domain-containing guanine exchange factor|Src homology 3 domain-containing guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 26
Swissprots Q9H9R2 Q9UFW5 Q6Q8Q8 E9PBD0 Q96DR6 B3KVP8 Q96AW8 Q96DR7 Q68CL1 Q9H9D7 Q6AZ96
Accessions EAW78764 Q96DR7 AB073386 BAD38637 AF415175 AAL27001 AF415176 AAL27002 AK022655 BAB14159 AK022884 BAB14292 AK123040 BAG53860 AK127282 BAG54472 AL117429 CAB55918 AY552599 AAS59842 BC016628 AAH16628 BC078655 AAH78655 DA248533 DB069290 XM_011512672 XP_011510974 XM_011546470 XP_011544772 NM_001251962 NP_001238891 NM_001251963 NP_001238892 NM_015595 NP_056410
Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
Subcellular Location Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}.
Tissue Specificity Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269|PubMed:12697679, ECO:0000269|PubMed:15133129}.
Top Pathways Bacterial invasion of epithelial cells

SGEF (E-5) - sc-514048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SGEF (E-5): sc-514048. Western blot analysis of SGEF expression in WI-38 whole cell lysate.

SGEF (C-15) - sc-103213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SGEF (C-15): sc-103213. Western blot analysis of SGEF expression in WI 38 whole cell lysate.

SGEF (S-17) - sc-103215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SGEF (S-17): sc-103215. Western blot analysis of SGEF expression in HeLa (A) and SK-BR-3 (B) whole cell lysates.

Anti-SGEF antibody - ab129265 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SGEF antibody (ab129265) at 1/100 dilution + NCI-H460 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-SGEF antibody - ab98848 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SGEF antibody (ab98848) at 1 µg/ml + OVCAR-3 cell lysate at 10 µg

Anti-ARHGEF26 / SGEF Antibody (aa377-406, APC) - LS-C240669 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406, AP) - LS-C240671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406, Biotin) - LS-C240672 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406, PE) - LS-C240677 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406, FITC) - LS-C240673 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406, Azide-free, HRP) - LS-C248142 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (aa377-406) - LS-C325054 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF26 / SGEF Antibody (N-Terminus) - LS-C107806 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ARHGEF26 / SGEF antibody LS-C107806 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-ARHGEF26 / SGEF Antibody (aa378-406) - LS-C169041 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SGEF Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

SGEF Antibody - NBP1-88006 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SGEF Antibody [NBP1-88006] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

SGEF Antibody - NBP1-70702 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SGEF, (N-terminal) antibody produced in rabbit - SAB2105003 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SGEF, antibody produced in rabbit: <B>Cat. No. SAB2105003</B>: Immunoblotting analysis of SGEF in OVCAR-3 cell lysate with SGEF anitbody at 1 μg/mL.

ANTI-ARHGEF26 antibody produced in rabbit - HPA017722 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AC018452.11: <B>Cat. No. HPA017722</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenum shows moderate cytoplasmic positivity in glandular cells as well as in the muscular layers.

ANTI-SGEF (CENTER) antibody produced in rabbit - SAB1307043 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SGEF (Center): <B>Cat. No. SAB1307043</B>: SGEF Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35 μg/lane).

ARHGEF26 antibody - N-terminal region (ARP55292_P050) - ARP55292_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SGEF-Antibody-Center - AP13325c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SGEF Antibody (Center) (Cat. #AP13325c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGEF antibody detected the SGEF protein (arrow).

SGEF Antibody - middle region (OAAB09636) - OAAB09636 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SGEF antibody - 70R-3508 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SGEF Antibody - abx027344 from Abbexa

Host Rabbit
Clonality Polyclonal

ARHGEF26 / SGEF antibody - 12493-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
PC-3 cells were subjected to SDS PAGE followed by western blot with 12493-1-AP(SGEF antibody) at dilution of 1:300
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