ARHGEF26

Gene Symbol ARHGEF26
Entrez Gene 26084
Alt Symbol CSGEF, HMFN1864, SGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 26
Other Description SH3 domain-containing guanine exchange factor|Src homology 3 domain-containing guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 26
Swissprots Q9H9R2 Q9UFW5 Q6Q8Q8 E9PBD0 Q96DR6 B3KVP8 Q96AW8 Q96DR7 Q68CL1 Q9H9D7 Q6AZ96
Accessions EAW78764 Q96DR7 AB073386 BAD38637 AF415175 AAL27001 AF415176 AAL27002 AK022655 BAB14159 AK022884 BAB14292 AK123040 BAG53860 AK127282 BAG54472 AL117429 CAB55918 AY552599 AAS59842 BC016628 AAH16628 BC078655 AAH78655 DA248533 DB069290 XM_011512672 XP_011510974 XM_011546470 XP_011544772 NM_001251962 NP_001238891 NM_001251963 NP_001238892 NM_015595 NP_056410
Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
Subcellular Location Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}.
Tissue Specificity Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269|PubMed:12697679, ECO:0000269|PubMed:15133129}.
Top Pathways Bacterial invasion of epithelial cells

SGEF CRISPR/Cas9 KO Plasmid (h) - sc-409874 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF HDR Plasmid (h) - sc-409874-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF Double Nickase Plasmid (h) - sc-409874-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF Double Nickase Plasmid (h2) - sc-409874-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF CRISPR Activation Plasmid (h) - sc-409874-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF CRISPR Activation Plasmid (h2) - sc-409874-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF Lentiviral Activation Particles (h) - sc-409874-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF Lentiviral Activation Particles (h2) - sc-409874-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SGEF siRNA (h) - sc-78233 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SGEF shRNA Plasmid (h) - sc-78233-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SGEF shRNA (h) Lentiviral Particles - sc-78233-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU086541 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3453 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3453 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ARHGEF26 siRNA (Human) - CRH8698 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARHGEF26 - MBS8226467 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARHGEF26 (NM_015595.3) - SHH239802 from Creative biogene

Category siRNA
Species Reactivities Human

ARHGEF26 shRNA Plasmid (Human) - CHH8698 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARHGEF26 miRNA 3'UTR clone - MiUTR4H-TG00482 from Creative biogene

Species Reactivities Human
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