SPPL2A

Gene Symbol SPPL2A
Entrez Gene 84888
Alt Symbol IMP3, PSL2
Species Human
Gene Type protein-coding
Description signal peptide peptidase like 2A
Other Description IMP-3|SPP-like 2A|intramembrane cleaving protease|intramembrane protease 3|presenilin-like protein 2|signal peptide peptidase-like 2A
Swissprots B2RDS0 Q8TAW1 Q96SZ8 Q8TCT8
Accessions EAW77410 Q8TCT8 AA988423 AJ345028 CAC87789 AJ420896 CAD13133 AK027446 BAB55117 AK075454 BAC11630 AK315651 BAG38017 AY169314 AAO12539 BC025740 AAH25740 DA023801 XM_005254722 XP_005254779 XM_011522113 XP_011520415 XM_011522114 XP_011520416 XM_011522115 XP_011520417 XM_011522116 XP_011520418 NM_032802 NP_116191
Function Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014}.
Subcellular Location Late endosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:16829952}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15385547}.

SPPL2a (Y-12) - sc-83045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPPL2a (Y-12): sc-83045. Western blot analysis of SPPL2a expression in SH-SY5Y (A), Jurkat (B), HuT 78 (C) and Ramos (D) whole cell lysates.

SPPL2a (C-14) - sc-83042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SPPL2a antibody - ab38304 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SPPL2a antibody (ab38304) at 1/100 dilution + Jurkat cell lysate

Anti-SPPL2A / IMP3 Antibody (N-Terminus, APC) - LS-C220758 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus, AP) - LS-C220757 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus, Biotin) - LS-C220759 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus, FITC) - LS-C220760 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus, Azide-free, HRP) - LS-C220761 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus) - LS-C330670 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (N-Terminus, PE) - LS-C220762 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPPL2A / IMP3 Antibody (aa108-138) - LS-C100059 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

SPPL2a Antibody - NBP1-87512 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SPPL2a Antibody [NBP1-87512] - Staining of human cell line U-2 OS shows positivity in cytoplasm.

SPPL2a Antibody - H00084888-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

ANTI-SPPL2A(N-TERMINAL) antibody produced in rabbit - SAB1307106 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPPL2a (N-term): <B>Cat. No. SAB1307106</B>: Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SPPL2A antibody produced in rabbit - HPA036062 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AC012100.1: <B>Cat. No. HPA036062</B>: Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells of tubules.

Anti-SPPL2a (N-term) antibody produced in rabbit - SAB1300346 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPPL2A (N-term) Antibody: <B>Cat. No. SAB1300346</B>: SPPL2A in human placenta tissue with Anti-SPPL2A (N-term) Antibody at 40 μg/mL.

Anti-SPPL2a (C-term) antibody produced in rabbit - SAB1300766 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SPPL2a-Antibody-N-term - AP6312a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
The anti-SPPL2a Pab (Cat. #AP6312a) is used in Western blot to detect SPPL2a in Jurkat cell lysate.

SPPL2a Antibody - N-terminal region (OAAB16632) - OAAB16632 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SPPL2A antibody - 13255-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Human colon were subjected to SDS PAGE followed by western blot with 13255-1-AP(SPPL2A Antibody) at dilution of 1:800

SPPL2A (N-term) antibody - AP13336PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

SPPL2A antibody - H00084888-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

SPPL2A antibody - H00084888-M02 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C7

SPPL2A antibody - PAB4907 from Acris Antibodies

Prices $420.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2A polyclonal antibody ( Cat # PAB4907 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.

SPPL2A antibody - 13255-1-AP from Proteintech Group

Prices $279.00
Sizes con: 34 μg/150μl
Host Rabbit
Clonality Polyclonal
human colon tissue were subjected to SDS PAGE followed by western blot with 13255-1-AP(SPPL2A antibody) at dilution of 1:500
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