SPPL2A

Gene Symbol	SPPL2A
Entrez Gene	84888
Alt Symbol	IMP3, PSL2
Species	Human
Gene Type	protein-coding
Description	signal peptide peptidase like 2A
Other Description	IMP-3|SPP-like 2A|intramembrane cleaving protease|intramembrane protease 3|presenilin-like protein 2|signal peptide peptidase-like 2A
Swissprots	B2RDS0 Q8TAW1 Q96SZ8 Q8TCT8
Accessions	EAW77410 Q8TCT8 AA988423 AJ345028 CAC87789 AJ420896 CAD13133 AK027446 BAB55117 AK075454 BAC11630 AK315651 BAG38017 AY169314 AAO12539 BC025740 AAH25740 DA023801 XM_005254722 XP_005254779 XM_011522113 XP_011520415 XM_011522114 XP_011520416 XM_011522115 XP_011520417 XM_011522116 XP_011520418 NM_032802 NP_116191
Function	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:16829952}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15385547}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPPL2a protein fragment - ab164680 from Abcam Category Protein Source Wheat germ Species Human

SPPL2A / IMP3 Antibody Blocking Peptide - LS-E8201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SPPL2a Protein - H00084888-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SPPL2a-Antibody-N-term-Blocking-Peptide - BP6312a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPPL2A - H00084888-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SPPL2A - H00084888-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SPPL2A fusion protein - ag3935 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SPPL2a Recombinant Protein Antigen - NBP1-87512PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SPPL2a-Antibody-C-term-Blocking-Peptide - BP6312c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPPL2A Peptide, Human - M34GP15084H from Creative Peptides Category Peptide Source Synthetic. Species Human

SPPL2a Recombinant Protein Antigen - NBP2-57121PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Signal peptide peptidase-like 2A (SPPL2A), Recombinant Protein - MBS7097251 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more