| Gene Symbol |
SPPL2A
|
| Entrez Gene |
84888
|
| Alt Symbol |
IMP3, PSL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal peptide peptidase like 2A
|
| Other Description |
IMP-3|SPP-like 2A|intramembrane cleaving protease|intramembrane protease 3|presenilin-like protein 2|signal peptide peptidase-like 2A
|
| Swissprots |
B2RDS0 Q8TAW1 Q96SZ8 Q8TCT8
|
| Accessions |
EAW77410 Q8TCT8 AA988423 AJ345028 CAC87789 AJ420896 CAD13133 AK027446 BAB55117 AK075454 BAC11630 AK315651 BAG38017 AY169314 AAO12539 BC025740 AAH25740 DA023801 XM_005254722 XP_005254779 XM_011522113 XP_011520415 XM_011522114 XP_011520416 XM_011522115 XP_011520417 XM_011522116 XP_011520418 NM_032802 NP_116191
|
| Function |
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014}.
|
| Subcellular Location |
Late endosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:16829952}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15385547}.
|