EPHA8

Gene Symbol	EPHA8
Entrez Gene	2046
Alt Symbol	EEK, EK3, HEK3
Species	Human
Gene Type	protein-coding
Description	EPH receptor A8
Other Description	EPH- and ELK-related kinase|EPH- and ELK-related tyrosine kinase|EPH-like kinase 3|ephrin type-A receptor 8|hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine-protein kinase receptor EEK|tyrosylprotein kinase
Swissprots	Q9P269 Q9NUA9 Q8IUX6 P29322 Q6IN80
Accessions	CAA41980 CAT16941 EAW95013 P29322 AB040892 BAA95983 BC038796 AAH38796 BC072417 AAH72417 BC141436 AAI41437 XM_011540968 XP_011539270 XM_011540969 XP_011539271 XM_011540970 XP_011539272 XM_011540971 XP_011539273 XM_011540972 XP_011539274 XM_011540973 XP_011539275 XM_011540974 XP_011539276 XM_011540975 XP_011539277 XR_946576 XR_946577 XR_946578 NM_001006943 NP_001006944 NM_020526 NP_065387
Function	Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EphA8 (H-70) - sc-25460 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EphA8 (R-19) - sc-7287 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphA8 (T-13) - sc-31246 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-EPHA8 / EPH Receptor A8 Antibody (aa309-324) - LS-C147870 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EPHA8 / EPH Receptor A8 Antibody (aa309-324) - LS-C6545 from LifeSpan Bioscience Prices $385.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EPHA8 / EPH Receptor A8 Antibody (aa70-150, clone 13B255) - LS-C183472 from LifeSpan Bioscience Prices $425.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 13B255

Anti-EPHA8 / EPH Receptor A8 Antibody (aa70-150, clone 9A12D8) - LS-C171426 from LifeSpan Bioscience Prices $345.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9A12D8

Anti-EPHA8 / EPH Receptor A8 Antibody (aa1-277) - LS-C185885 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

EphA8 Antibody - NBP1-32864 from Novus Biologicals Host Rabbit Clonality Polyclonal

EphA8 Antibody - NBP2-24843 from Novus Biologicals Prices $199.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

EphA8 Antibody - NBP1-31669 from Novus Biologicals Host Rabbit Clonality Polyclonal

EphA8 Antibody - NBP1-84893 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

EphA8 Antibody (9A12D8) - NBP1-51550 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9A12D8

Rabbit Anti-EphA8 Polyclonal Antibody - bs-7035R from Bioss Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EPHA8 (N-terminal) antibody produced in rabbit - SAB2700960 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EPHA8 antibody produced in rabbit - SAB2700973 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EphA8 (C-term) antibody produced in rabbit - SAB1300109 from Sigma-Aldrich Prices $291.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EPHA8 antibody produced in rabbit - HPA031433 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-EPHA8 antibody produced in mouse - SAB5300104 from Sigma-Aldrich Prices $347.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9A12D8

EPHA8 Antibody (OAAD00276) - OAAD00276 from Aviva Systems Biology Prices $335.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9A12D8

HDAC3-Antibody - AO1211a from Abgent, a WuXi AppTec company Prices $385.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7G6C5

EphA8 antibody - GTX10615 from GeneTex Prices $419.00 Sizes 50 μg Host Goat Clonality Polyclonal

EphA8 antibody [9A12D8] - GTX83167 from GeneTex Prices $319.00 Sizes 100 μl Host Mouse Clonality Monoclonal Clone 9A12D8

Mouse EphA8 Antibody - AF454 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat

Mouse EphA8 Affinity Purified Polyclonal Ab, Goat IgG - AF454-SP from R&D Systems Host Goat Clonality Polyclonal

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