| Gene Symbol | EPHA8 |
|---|---|
| Entrez Gene | 2046 |
| Alt Symbol | EEK, EK3, HEK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A8 |
| Other Description | EPH- and ELK-related kinase|EPH- and ELK-related tyrosine kinase|EPH-like kinase 3|ephrin type-A receptor 8|hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine-protein kinase receptor EEK|tyrosylprotein kinase |
| Swissprots | Q9P269 Q9NUA9 Q8IUX6 P29322 Q6IN80 |
| Accessions | CAA41980 CAT16941 EAW95013 P29322 AB040892 BAA95983 BC038796 AAH38796 BC072417 AAH72417 BC141436 AAI41437 XM_011540968 XP_011539270 XM_011540969 XP_011539271 XM_011540970 XP_011539272 XM_011540971 XP_011539273 XM_011540972 XP_011539274 XM_011540973 XP_011539275 XM_011540974 XP_011539276 XM_011540975 XP_011539277 XR_946576 XR_946577 XR_946578 NM_001006943 NP_001006944 NM_020526 NP_065387 |
| Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}. |
| Top Pathways | Axon guidance |