EPHA8

Gene Symbol	EPHA8
Entrez Gene	2046
Alt Symbol	EEK, EK3, HEK3
Species	Human
Gene Type	protein-coding
Description	EPH receptor A8
Other Description	EPH- and ELK-related kinase|EPH- and ELK-related tyrosine kinase|EPH-like kinase 3|ephrin type-A receptor 8|hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine-protein kinase receptor EEK|tyrosylprotein kinase
Swissprots	Q9P269 Q9NUA9 Q8IUX6 P29322 Q6IN80
Accessions	CAA41980 CAT16941 EAW95013 P29322 AB040892 BAA95983 BC038796 AAH38796 BC072417 AAH72417 BC141436 AAI41437 XM_011540968 XP_011539270 XM_011540969 XP_011539271 XM_011540970 XP_011539272 XM_011540971 XP_011539273 XM_011540972 XP_011539274 XM_011540973 XP_011539275 XM_011540974 XP_011539276 XM_011540975 XP_011539277 XR_946576 XR_946577 XR_946578 NM_001006943 NP_001006944 NM_020526 NP_065387
Function	Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Eph receptor A8 protein fragment - ab125601 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

EphA8 Peptide - P2630 from Novus Biologicals Category Peptide Species Human

EphA8-Antibody-C-term-Blocking-Peptide - BP7613b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human EphA8 Fc Chimera, CF - 6828-A8-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

EPHA8 - P5547 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EPHA8 fusion protein - ag4638 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

EPHA8 fusion protein - ag4503 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EPH Receptor A8, GST-tagged - EPHA8-698H from Creative Biomart Category Protein Source Insect cells.

Recombinant Human EPHA8, GST-tagged - EPHA8-6999H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human EPHA8 - EPHA8-346H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human EPHA8, Fc Chimera - EPHA8-727H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Human EPH Receptor A8, His-tagged - EPHA8-2145H from Creative Biomart Category Protein Source mammalian cells .

EphA8 Protein, active, 10 µg - 14-673 from EMD Millipore Category Protein Prices $311.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

EphA8 Protein, active, 250 µg - 14-673M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-673) and in bulk (cat#14-673-K) Source expressed by baculovirus in Sf21 cells

EPHA8 protein-GST fusion - 009-001-R90 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

EPHA8 protein-GST fusion - 009-001-R90S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Ephrin type-A receptor 8(EPHA8) - CSB-YP007728HU CSB-EP007728HU CSB-BP007728HU CSB-MP007728HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human EphA8 Fc Chimera Protein, CF - 6828-A8 from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human EphA8 (Glu31-Thr542) Accession # NP_065387 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

EPHA8 (C-term DDK/His tag, transcript variant 1) - TP700145 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human EPHA8 His - CSI13402 from Cell Science Prices $615.00 Sizes 10 μg Species Human

EphA8 Recombinant Protein Antigen - NBP1-84893PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EphA8-Antibody-N-term-Blocking-Peptide - BP7613a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPHA8 Peptide, Human - M34GP04991H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human Ephrin Type-A Receptor 8 protein (C-Fc) - orb311738 from Biorbyt Category Protein Prices $255.00, $451.00, $1,411.00, $2,108.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human EPHA8 protein - orb391670 from Biorbyt Category Protein Prices $323.00, $553.00, $2,661.00 Sizes 10 μl (Trial size), 50 μl, 500 μl Species Human

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