| Gene Symbol | ARHGAP5 |
|---|---|
| Entrez Gene | 394 |
| Alt Symbol | GFI2, RhoGAP5, p190-B, p190BRhoGAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho GTPase activating protein 5 |
| Other Description | growth factor independent 2|p100 RasGAP-associated p105 protein|p105 RhoGAP|rho GTPase-activating protein 5|rho-type GTPase-activating protein 5 |
| Swissprots | D3DS89 Q05BU8 D3DS90 A1L376 Q59ER0 Q6DHZ3 A1L375 Q13017 A8KAA1 Q05BE8 |
| Accessions | CCQ43130 EAW65935 EAW65936 EAW65937 EAW65938 Q13017 AB209751 BAD92988 AK023014 AK023468 AK292966 BAF85655 AK307454 AL045112 AY316523 AAP83192 BC032723 AAH32723 BC050059 AAH50059 BC075799 AAH75799 BC129928 AAI29929 BC129929 AAI29930 CA945100 U17032 AAA95963 XM_005267635 XP_005267692 XM_005267636 XP_005267693 NM_001030055 NP_001025226 NM_001173 NP_001164 |
| Function | GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP. |
| Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. |
| Tissue Specificity | Expressed in kidney, brain, liver and lung. |
| Top Pathways | Focal adhesion, Leukocyte transendothelial migration |