Gene Symbol |
REG3A
|
Entrez Gene |
5068
|
Alt Symbol |
HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
regenerating islet-derived 3 alpha
|
Other Description |
PAP homologous protein|REG-3-alpha|hepatocarcinoma-intestine-pancreas|hepatointestinal pancreatic protein|human proislet peptide|pancreatic beta cell growth factor|pancreatitis-associated protein 1|proliferation-inducing protein 34|proliferation-inducing protein 42|reg III-alpha|regenerating islet-derived protein 3-alpha|regenerating islet-derived protein III-alpha
|
Swissprots |
Q06141
|
Accessions |
AAA60020 AAX93047 BAA21104 CCQ43184 EAW99570 EAW99571 EAW99572 Q06141 AK291973 BAF84662 AK311523 AK311526 AY544128 AAT11159 AY544130 AAT11161 BC036776 AAH36776 BQ777112 D13510 BAA02728 DC300833 DQ890717 ABM81643 DQ893897 ABM84823 M84337 AAA36415 S51768 AAB24642 X68641 CAA48605 NM_002580 NP_002571 NM_138937 NP_620354 NM_138938 NP_620355
|
Function |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000269|PubMed:16931762}.
|
Subcellular Location |
Secreted. Note=Found in the apical region of pancreatic acinar cells.
|
Tissue Specificity |
Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. {ECO:0000269|PubMed:1469087, ECO:0000269|PubMed:22727489}.
|