REG3A
| Gene Symbol | REG3A |
|---|---|
| Entrez Gene | 5068 |
| Alt Symbol | HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | regenerating islet-derived 3 alpha |
| Other Description | PAP homologous protein|REG-3-alpha|hepatocarcinoma-intestine-pancreas|hepatointestinal pancreatic protein|human proislet peptide|pancreatic beta cell growth factor|pancreatitis-associated protein 1|proliferation-inducing protein 34|proliferation-inducing protein 42|reg III-alpha|regenerating islet-derived protein 3-alpha|regenerating islet-derived protein III-alpha |
| Swissprots | Q06141 |
| Accessions | AAA60020 AAX93047 BAA21104 CCQ43184 EAW99570 EAW99571 EAW99572 Q06141 AK291973 BAF84662 AK311523 AK311526 AY544128 AAT11159 AY544130 AAT11161 BC036776 AAH36776 BQ777112 D13510 BAA02728 DC300833 DQ890717 ABM81643 DQ893897 ABM84823 M84337 AAA36415 S51768 AAB24642 X68641 CAA48605 NM_002580 NP_002571 NM_138937 NP_620354 NM_138938 NP_620355 |
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000269|PubMed:16931762}. |
| Subcellular Location | Secreted. Note=Found in the apical region of pancreatic acinar cells. |
| Tissue Specificity | Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. {ECO:0000269|PubMed:1469087, ECO:0000269|PubMed:22727489}. |
Reg IIIα CRISPR/Cas9 KO Plasmid (h) - sc-404278 from Santa Cruz Biotechnology
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Reg IIIα HDR Plasmid (h) - sc-404278-HDR from Santa Cruz Biotechnology
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Reg IIIα Double Nickase Plasmid (h) - sc-404278-NIC from Santa Cruz Biotechnology
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Reg IIIα Double Nickase Plasmid (h2) - sc-404278-NIC-2 from Santa Cruz Biotechnology
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Reg IIIα CRISPR Activation Plasmid (h) - sc-404278-ACT from Santa Cruz Biotechnology
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Reg IIIα CRISPR Activation Plasmid (h2) - sc-404278-ACT-2 from Santa Cruz Biotechnology
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Reg IIIα Lentiviral Activation Particles (h) - sc-404278-LAC from Santa Cruz Biotechnology
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Reg IIIα Lentiviral Activation Particles (h2) - sc-404278-LAC-2 from Santa Cruz Biotechnology
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REG IIIα siRNA (h) - sc-61450 from Santa Cruz Biotechnology
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REG IIIα shRNA Plasmid (h) - sc-61450-SH from Santa Cruz Biotechnology
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REG IIIα shRNA (h) Lentiviral Particles - sc-61450-V from Santa Cruz Biotechnology
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Reg3A RNAi - H00005068-R03 from Novus Biologicals
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Reg3A RNAi - H00005068-R01 from Novus Biologicals
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MISSION® esiRNA - EHU113481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18132 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18132 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01134 from Sigma-Aldrich
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REG3A siRNA (Human) - CRH3368 from Cohesion Biosciences
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Reg3A RNAi - H00005068-R02 from Novus Biologicals
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REG3A - MBS8237267 from MyBioSource
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shRNA set against Human REG3A (NM_002580.2) - SHH391740 from Creative biogene
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Human REG3A siRNA - orb263870 from Biorbyt
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REG3A shRNA Plasmid (Human) - CHH3368 from Cohesion Biosciences
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REG3A miRNA 3'UTR clone - MiUTR3H-01663 from Creative biogene
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REG3A miRNA 3'UTR clone - MiUTR3H-01664 from Creative biogene
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