OGT

Gene Symbol OGT
Entrez Gene 8473
Alt Symbol HRNT1, O-GLCNAC
Species Human
Gene Type protein-coding
Description O-linked N-acetylglucosamine (GlcNAc) transferase
Other Description O-GlcNAc transferase p110 subunit|O-GlcNAc transferase subunit p110|O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)|O-linked N-acetylglucosamine transferase 110 kDa subunit|UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit|UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase|uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
Swissprots Q8WWM8 O15294 Q96CC1 Q7Z3K0 Q9UG57
Accessions CAC86127 CAC86128 CAC86129 EAX05285 EAX05286 EAX05287 O15294 AF070560 AF147394 AF223393 AAF31458 AK300267 BAG62028 AK313530 AL049950 AL050366 CAB62528 AL833085 CAD89970 BC014434 AAH14434 BC015144 BC038180 AAH38180 BX537844 CAD97853 CB857907 DA460761 DQ893623 ABM84549 DQ896848 ABM87847 U77413 AAB63466 XM_005262308 XP_005262365 NM_181672 NP_858058 NM_181673 NP_858059 NM_003605
Function Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin s
Subcellular Location Isoform 4: Cytoplasm. Nucleus.
Tissue Specificity Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver. {ECO:0000269|PubMed:9083068}.
Top Pathways Other types of O-glycan biosynthesis

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT), Human, ELISA Kit - CSB-EL016315HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) , ELISA Kit - MBS911624 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <9.38 pg/ml
Range 37.5 pg/ml-2400 pg/ml

ELISA Kit for O-Linked-N-Acetylglucosamine Transferase (OGT) - SEH501Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.59ng/mL.
Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit(OGT) ELISA kit - CSB-EL016315HU from Cusabio

Category ELISA Kit
Sensitivity 9.38 pg/ml.
Range 37.5 pg/ml-2400 pg/ml

ELISA Kit for O-Linked-N-Acetylglucosamine Transferase (OGT) - SEH501Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.59ng/mL.
Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Human OGT / O-GLCNAC ELISA Kit (Sandwich ELISA) - LS-F25529 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.59 ng/ml
Range 1.56-100 ng/ml

Human OGT ELISA Kit - E027193 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human OGT is typically less than 9.38 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

OGT ELISA Kit (Human) (OKCD01956) - OKCD01956 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 0.59 ng/mL
Range 1.56 - 100 ng/mL

anti-OGT antibody - ARG55203 from Arigo Biolaboratories

Category ELISA Kit

anti-O-GlcNAc antibody [9H6] - ARG22637 from Arigo Biolaboratories

Category ELISA Kit

anti-OGT antibody - ARG64143 from Arigo Biolaboratories

Category ELISA Kit

OGT ELISA Kit (Human) (OKCA02153) - OKCA02153 from Aviva Systems Biology

Category ELISA Kit
Sensitivity 9.38 pg/mL
Range 37.5 pg/mL-2,400 pg/mL
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