OGT

Gene Symbol	OGT
Entrez Gene	8473
Alt Symbol	HRNT1, O-GLCNAC
Species	Human
Gene Type	protein-coding
Description	O-linked N-acetylglucosamine (GlcNAc) transferase
Other Description	O-GlcNAc transferase p110 subunit|O-GlcNAc transferase subunit p110|O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)|O-linked N-acetylglucosamine transferase 110 kDa subunit|UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit|UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase|uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
Swissprots	Q8WWM8 O15294 Q96CC1 Q7Z3K0 Q9UG57
Accessions	CAC86127 CAC86128 CAC86129 EAX05285 EAX05286 EAX05287 O15294 AF070560 AF147394 AF223393 AAF31458 AK300267 BAG62028 AK313530 AL049950 AL050366 CAB62528 AL833085 CAD89970 BC014434 AAH14434 BC015144 BC038180 AAH38180 BX537844 CAD97853 CB857907 DA460761 DQ893623 ABM84549 DQ896848 ABM87847 U77413 AAB63466 XM_005262308 XP_005262365 NM_181672 NP_858058 NM_181673 NP_858059 NM_003605
Function	Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin s
Subcellular Location	Isoform 4: Cytoplasm. Nucleus.
Tissue Specificity	Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver. {ECO:0000269|PubMed:9083068}.
Top Pathways	Other types of O-glycan biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OGT / O-Linked N-Acetylglucosamine Transferase full length protein - ab131881 from Abcam Category Protein Source Wheat germ Species Human

Human OGT / O-Linked N-Acetylglucosamine Transferase protein fragment - ab91749 from Abcam Category Protein Source E. coli Species Human

OGT / O-GLCNAC Antibody Blocking Peptide - LS-E8392 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OGT / O-GLCNAC Antibody Blocking Peptide - LS-E26269 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human O-GlcNAc Transferase p110 subunit Protein - H00008473-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

OGT-Antibody-C-term-Blocking-Peptide - BP6695b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OGT blocking peptide - GTX89131-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human O-GlcNAcTransferase/OGT, CF - 8446-GT-010 from R&D Systems Category Protein Source E. coli-derived, Cys323-Glu1041, with C-terminal 6-His tag

Recombinant Human O-GlcNAcTransferase/OGT, CF - 8446-GT-050 from R&D Systems Category Protein Source E. coli-derived, Cys323-Glu1041, with C-terminal 6-His tag

Human OGT protein - orb244420 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

OGT Blocking Peptide - 33R-1533 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

OGT / O-linked N-acetylglucosamine Transferase Peptide - AC21-1101-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

OGT - H00008473-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

OGT - H00008473-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

OGT Peptide - 45-995P from ProSci Category Peptide Species Mouse, Rat

OGT fusion protein - Ag2160 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human OGT, GST-tagged - OGT-1448H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human OGT - OGT-407H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human OGT protein, His-tagged - OGT-940H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransfera - CSB-EP016315HU CSB-BP016315HU CSB-MP016315HU from Cusabio Category Peptide Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransfera - CSB-EP016315HU from Cusabio Category Peptide Source E.coli Species Human

Recombinant Human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransfera - CSB-YP016315HU CSB-BP016315HU CSB-MP016315HU from Cusabio Category Peptide Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human O-GlcNAcTransferase/OGT Protein, CF - 8446-GT from R&D Systems Category Protein Prices $359.00, $529.00 Sizes 10 µg, 50 µg Source E. coli -derived Cys323-Glu1041, with C-terminal 6-His tag Species Human

OGT (transcript variant 1) - TP306822 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

OGT (transcript variant 2) - TP324481 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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