| Gene Symbol |
Gm6484
|
| Entrez Gene |
624219
|
| Alt Symbol |
Angptl8, EG624219, Rifl
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
predicted gene 6484
|
| Other Description |
angiopoietin-like protein 8|betatrophin|hepatocellular carcinoma-associated protein TD26 homolog|lipasin|refeeding-induced fat and liver protein
|
| Swissprots |
Q8R1L8
|
| Accessions |
Q8R1L8 BC024408 AAH24408 BC038127 BC051501 AAH51501 CK791522 KM253766 AIU96340 NM_001080940 NP_001074409
|
| Function |
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787). According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577). According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787). {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23150577, ECO:0000269|PubMed:24043787}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:23623304}.
|
| Tissue Specificity |
Expressed in liver and fat. Enriched in white and brown adipose tissues. {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23623304}.
|