Gene Symbol | Gm6484 |
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Entrez Gene | 624219 |
Alt Symbol | Angptl8, EG624219, Rifl |
Species | Mouse |
Gene Type | protein-coding |
Description | predicted gene 6484 |
Other Description | angiopoietin-like protein 8|betatrophin|hepatocellular carcinoma-associated protein TD26 homolog|lipasin|refeeding-induced fat and liver protein |
Swissprots | Q8R1L8 |
Accessions | Q8R1L8 BC024408 AAH24408 BC038127 BC051501 AAH51501 CK791522 KM253766 AIU96340 NM_001080940 NP_001074409 |
Function | Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787). According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577). According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787). {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23150577, ECO:0000269|PubMed:24043787}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:23623304}. |
Tissue Specificity | Expressed in liver and fat. Enriched in white and brown adipose tissues. {ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23623304}. |
EG624219 siRNA (m) - sc-143895 from Santa Cruz Biotechnology
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EG624219 shRNA Plasmid (m) - sc-143895-SH from Santa Cruz Biotechnology
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EG624219 shRNA (m) Lentiviral Particles - sc-143895-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU183961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32451 from Sigma-Aldrich
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GM6484 siRNA (Mouse) - CRN5206 from Cohesion Biosciences
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GM6484 - MBS8238487 from MyBioSource
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Mouse GM6484 siRNA - orb294681 from Biorbyt
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GM6484 shRNA Plasmid (Mouse) - CHN5206 from Cohesion Biosciences
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GM6484 miRNA 3'UTR clone - MiUTR1M-04278 from Creative biogene
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