ADAMTS13
| Gene Symbol | ADAMTS13 |
|---|---|
| Entrez Gene | 11093 |
| Alt Symbol | ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADAM metallopeptidase with thrombospondin type 1 motif, 13 |
| Other Description | A disintegrin and metalloproteinase with thrombospondin motifs 13|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13|vWF-cleaving protease|von Willebrand factor-cleaving protease |
| Swissprots | Q9UGQ1 Q96L37 Q710F6 Q9H0G3 Q711T8 Q6UY16 Q76LX8 |
| Accessions | AAS54901 AAS54902 AAS54903 AAS54904 ABD72606 ADD92168 CAI12850 CAI12851 CAI12852 EAW88083 EAW88084 EAW88085 EAW88086 EAW88087 EAW88088 Q76LX8 AB069698 BAB69487 AF414400 AAL11094 AF414401 AAL11095 AJ011374 CAB66157 AJ305314 CAC83682 AJ420810 CAD12729 AJ420811 CAD12730 AK124983 BAG54119 AK292439 BAF85128 AL136809 CAB66743 AV655072 AW197188 AY055376 AAL17652 AY358118 AAQ88485 BC034404 BC039251 BC103828 BC103829 BC103830 BC172369 AAI72369 DB069518 XM_011518174 XP_011516476 XM_011518175 XP_011516477 XM_011518176 XP_011516478 XM_011518177 XP_011516479 XM_011518178 XP_011516480 XM_011518179 XP_011516481 XM_011518180 XP_011516482 XM_011548750 XP_011547052 XM_011548751 XP_011547053 XM_011548752 XP_011547054 XM_011548753 XP_011547055 XM_011548754 XP_011547056 XM_011548755 XP_011547057 XM_011548756 XP_011547058 NM_139025 NP_620594 NM_139026 NP_620595 NM_139027 NP_620596 NR_024514 NM_139028 |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269|PubMed:19880749}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12791682}. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats. |
| Tissue Specificity | Plasma. Expressed primarily in liver. {ECO:0000269|PubMed:11574066}. |
ADAMTS-13 CRISPR/Cas9 KO Plasmid (h) - sc-402782 from Santa Cruz Biotechnology
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ADAMTS-13 HDR Plasmid (h) - sc-402782-HDR from Santa Cruz Biotechnology
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ADAMTS-13 Double Nickase Plasmid (h) - sc-402782-NIC from Santa Cruz Biotechnology
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ADAMTS-13 Double Nickase Plasmid (h2) - sc-402782-NIC-2 from Santa Cruz Biotechnology
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ADAMTS-13 CRISPR Activation Plasmid (h) - sc-402782-ACT from Santa Cruz Biotechnology
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ADAMTS-13 CRISPR Activation Plasmid (h2) - sc-402782-ACT-2 from Santa Cruz Biotechnology
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ADAMTS-13 Lentiviral Activation Particles (h) - sc-402782-LAC from Santa Cruz Biotechnology
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ADAMTS-13 Lentiviral Activation Particles (h2) - sc-402782-LAC-2 from Santa Cruz Biotechnology
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ADAMTS-13 siRNA (h) - sc-37058 from Santa Cruz Biotechnology
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ADAMTS-13 shRNA Plasmid (h) - sc-37058-SH from Santa Cruz Biotechnology
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ADAMTS-13 shRNA (h) Lentiviral Particles - sc-37058-V from Santa Cruz Biotechnology
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ADAMTS13 RNAi - H00011093-R04 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2532 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2532 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00430 from Sigma-Aldrich
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ADAMTS13 siRNA (Human) - CRH7585 from Cohesion Biosciences
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ADAMTS13 RNAi - H00011093-R02 from Novus Biologicals
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ADAMTS13 RNAi - H00011093-R03 from Novus Biologicals
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ADAMTS13 RNAi - H00011093-R01 from Novus Biologicals
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ADAMTS13 - MBS8221076 from MyBioSource
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shRNA set against Human ADAMTS13 (NM_139025.3) - SHH231758 from Creative biogene
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ADAMTS13 shRNA Plasmid (Human) - CHH7585 from Cohesion Biosciences
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ADAMTS13 miRNA 3'UTR clone - MiUTR3H-06580 from Creative biogene
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ADAMTS13 miRNA 3'UTR clone - MiUTR3H-06581 from Creative biogene
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ADAMTS13 miRNA 3'UTR clone - MiUTR3H-06582 from Creative biogene
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