FBXL2

Gene Symbol FBXL2
Entrez Gene 25827
Alt Symbol FBL2, FBL3
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 2
Other Description F-box protein FBL2/FBL3|F-box protein containing leucine-rich repeats|F-box/LRR-repeat protein 2
Swissprots Q9NVQ8 Q9Y3Y9 E9PD06 Q9UKA5 Q6IAN3 Q9UKC9 Q9UK27 B4DQV0
Accessions EAW64452 EAW64453 Q9UKC9 AF174589 AAF04510 AF176518 AAF03128 AF186273 AAD56248 AK001271 BAG50882 AK001438 BAA91691 AK096492 AK294209 BAG57520 AK297534 BAG59935 AK298967 BAG61062 AK299665 BAG61579 AK302218 BAG63574 AK303764 BAG64730 AK316229 BAH14600 AK316383 BAH14754 AL049953 CAB43222 AU124816 BC031556 AAH31556 CR457121 CAG33402 DA031508 DQ891164 ABM82090 DQ894345 ABM85271 XM_005265014 XP_005265071 XM_005265015 XP_005265072 XM_005265016 XP_005265073 XM_005265017 XP_005265074 XM_011533559 XP_011531861 XR_427262 NM_001171713 NP_001165184 NM_012157 NP_036289
Function Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary s
Subcellular Location Membrane {ECO:0000269|PubMed:15893726}; Lipid-anchor {ECO:0000269|PubMed:15893726}.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269|PubMed:10531037}.

FBL2 (D-17) - sc-54359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBL2 (D-17): sc-54359. Western blot analysis of FBL2 expression in mouse heart tissue extract.

FBL2 (I-14) - sc-54360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FBL2 (K-12) - sc-54361 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBL2 (K-12): sc-54361. Western blot analysis of FBL2 expression in rat liver tissue extract.

FBL2 (C-14) - sc-54358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FBXL2 Antibody (aa2-14) IHC-plus™ - LS-B10277 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-FBXL2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10277 concentration 10 ug/ml.

Anti-FBXL2 Antibody (aa366-395, AP) - LS-C214144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395, APC) - LS-C214145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395, Azide-free, HRP) - LS-C214148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395, FITC) - LS-C214149 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395, PE) - LS-C214150 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395, Biotin) - LS-C214147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa71-120) - LS-C101999 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBXL2 antibody LS-C101999 Western blot of Transfected 293T cell lysate.

Anti-FBXL2 Antibody (aa375-405) - LS-C321310 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL2 Antibody (aa366-395) - LS-C166074 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FBXL2 Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

FBXL2 Antibody - NBP1-33641 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBXL2 Antibody [NBP1-33641] - Sample (30 ug of whole cell lysate) A: Hela B: Raji 10% SDS PAGE, antibody diluted at 1:2000.

FBXL2 Antibody - NBP1-55279 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBXL2 Antibody [NBP1-55279] - Transfected 293T cell lysate, concentration 0.2-1 ug/ml.

FBXL2 Antibody - NB100-1289 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: FBXL2 Antibody [NB100-1289] - Staining of Human Frontal Cortex (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Anti-FBXL2 (N-terminal) antibody produced in rabbit - SAB2700864 from Sigma-Aldrich

Prices $326.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FBXL2 (N-terminal): <B>Cat. No. SAB2700864</B>: Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using FBXL2 antibody at 1:500 dilution.

Anti-FBL2/FBXL2 antibody produced in goat - SAB2500387 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FBL2 / FBXL2: <B>Cat. No. SAB2500387</B>: staining (0.3 μg/mL) of Human Brain lysates (RIPA buffer, 35 μg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-FBXL2, (N-terminal) antibody produced in rabbit - SAB2103107 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FBXL2, antibody produced in rabbit: <B>Cat. No. SAB2103107</B>: Immunoblotting analysis of FBXL2 in transfected 293T cell lysate with FBXL2 anitbody at 1 μg/mL.

FBXL2 antibody - N-terminal region (ARP43096_P050) - ARP43096_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FBXL2 Antibody - C-terminal region (OAAB02444) - OAAB02444 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

FBXL2-Antibody-C-term - AP5030b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of FBXL2 Antibody (C-term) (Cat. #AP5030b) in MDA-MB435 cell line lysates (35ug/lane).FBXL2 (arrow) was detected using the purified Pab.

FBL2--FBXL2-Antibody - AF1403a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1403a staining (0.3 µg/ml) of Human Brain lysates (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

FBXL2 antibody, N-term - GTX17018 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-FBL2 / FBXL2 antibody, N-term used in Western blot. GTX17018
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