FBXL2

Gene Symbol	FBXL2
Entrez Gene	25827
Alt Symbol	FBL2, FBL3
Species	Human
Gene Type	protein-coding
Description	F-box and leucine-rich repeat protein 2
Other Description	F-box protein FBL2/FBL3|F-box protein containing leucine-rich repeats|F-box/LRR-repeat protein 2
Swissprots	Q9NVQ8 Q9Y3Y9 E9PD06 Q9UKA5 Q6IAN3 Q9UKC9 Q9UK27 B4DQV0
Accessions	EAW64452 EAW64453 Q9UKC9 AF174589 AAF04510 AF176518 AAF03128 AF186273 AAD56248 AK001271 BAG50882 AK001438 BAA91691 AK096492 AK294209 BAG57520 AK297534 BAG59935 AK298967 BAG61062 AK299665 BAG61579 AK302218 BAG63574 AK303764 BAG64730 AK316229 BAH14600 AK316383 BAH14754 AL049953 CAB43222 AU124816 BC031556 AAH31556 CR457121 CAG33402 DA031508 DQ891164 ABM82090 DQ894345 ABM85271 XM_005265014 XP_005265071 XM_005265015 XP_005265072 XM_005265016 XP_005265073 XM_005265017 XP_005265074 XM_011533559 XP_011531861 XR_427262 NM_001171713 NP_001165184 NM_012157 NP_036289
Function	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary s
Subcellular Location	Membrane {ECO:0000269|PubMed:15893726}; Lipid-anchor {ECO:0000269|PubMed:15893726}.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269|PubMed:10531037}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBXL2 full length protein - ab161801 from Abcam Category Protein Source Wheat germ Species Human

Human FBXL2 peptide - ab23301 from Abcam Category Peptide Species Human

FBXL2 Antibody Blocking Peptide - LS-E25578 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXL2 Antibody Blocking Peptide - LS-E7701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXL2 Antibody Blocking Peptide - LS-E15865 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBXL2 Protein - H00025827-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXL2-Antibody-C-term-Blocking-Peptide - BP5030b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXL2 blocking peptide - GTX17018-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Rat, Bovine

Goat anti FBXL2 antibody Immunizing peptide - orb17814 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

FBXL2 Blocking Peptide - 33R-6734 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXL2 Peptide - AC21-0407-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FBXL2 / FBL2 / FBL3 - H00025827-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXL2 / FBL2 / FBL3 - H00025827-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBL2 Peptide - 45-571P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

FBXL2 fusion protein - ag4013 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human F-box/LRR-repeat protein 2(FBXL2) - CSB-YP892134HU CSB-EP892134HU CSB-BP892134HU CSB-MP892134HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXL2 / FBL2 / FBL3 - TP306390 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FBL2/FBXL2, Peptide - MBS425269 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Dog, Bovine

Recombinant human F-box/LRR-repeat protein 2 - CSB-EP892134HU from Cusabio Category Protein Source E.coli Species Human

FBXL2 Peptide, Human - M34GP05574H from Creative Peptides Category Peptide Source Synthetic. Species Human

FBXL2 Recombinant Protein (OPCA02546) - OPCA02546 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human FBXL2 protein - orb358221 from Biorbyt Category Protein Prices $221.00, $366.00, $646.00, $1,071.00, $1,692.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

F-box/LRR-repeat protein 2, Recombinant Protein - MBS1374022 from MyBioSource Category Protein Prices $110.00, $190.00, $285.00, $460.00, $750.00, $940.00, $1,065.00, $1,180.00, $1,260.00, $1,315.00, $1,355.00, $1,425.00, $1,945.00, $1,990.00, $2,170.00, $2,560.00 Sizes 10 µg (E-Coli), 50 µg (E-Coli), 100 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 1 mg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

FBXL2 fusion protein - Ag26653 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant human F-box/LRR-repeat protein 2 - AP71615 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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