| Gene Symbol |
FBXL2
|
| Entrez Gene |
25827
|
| Alt Symbol |
FBL2, FBL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 2
|
| Other Description |
F-box protein FBL2/FBL3|F-box protein containing leucine-rich repeats|F-box/LRR-repeat protein 2
|
| Swissprots |
Q9NVQ8 Q9Y3Y9 E9PD06 Q9UKA5 Q6IAN3 Q9UKC9 Q9UK27 B4DQV0
|
| Accessions |
EAW64452 EAW64453 Q9UKC9 AF174589 AAF04510 AF176518 AAF03128 AF186273 AAD56248 AK001271 BAG50882 AK001438 BAA91691 AK096492 AK294209 BAG57520 AK297534 BAG59935 AK298967 BAG61062 AK299665 BAG61579 AK302218 BAG63574 AK303764 BAG64730 AK316229 BAH14600 AK316383 BAH14754 AL049953 CAB43222 AU124816 BC031556 AAH31556 CR457121 CAG33402 DA031508 DQ891164 ABM82090 DQ894345 ABM85271 XM_005265014 XP_005265071 XM_005265015 XP_005265072 XM_005265016 XP_005265073 XM_005265017 XP_005265074 XM_011533559 XP_011531861 XR_427262 NM_001171713 NP_001165184 NM_012157 NP_036289
|
| Function |
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary s
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:15893726}; Lipid-anchor {ECO:0000269|PubMed:15893726}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269|PubMed:10531037}.
|