| Gene Symbol |
SH2D4A
|
| Entrez Gene |
63898
|
| Alt Symbol |
PPP1R38, SH2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH2 domain containing 4A
|
| Other Description |
SH2 domain-containing protein 4A|protein SH(2)A|protein phosphatase 1 regulatory subunit 38|protein phosphatase 1, regulatory subunit 38
|
| Swissprots |
Q5XKC1 B4DDR1 Q9H7F7 Q6NXE9 Q96C88 Q86YM2 Q9H788
|
| Accessions |
EAW63773 Q9H788 AK024620 BAB14935 AK024799 BAB15010 AK225052 AK293301 BAG56822 AY190323 AAO41715 BC014525 AAH14525 BC067117 AAH67117 BC082982 AAH82982 CA418381 DA952240 XM_011544610 XP_011542912 XM_011544611 XP_011542913 NM_001174159 NP_001167630 NM_001174160 NP_001167631 NM_022071 NP_071354
|
| Function |
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269|PubMed:12476414}.
|
![Western Blot: SH2D4A Overexpression Lysate (Adult Normal) [NBP2-06474] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SH2D4A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4778_SH2D4A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06474-img0001.jpg)