Gene Symbol | SH2D4A |
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Entrez Gene | 63898 |
Alt Symbol | PPP1R38, SH2A |
Species | Human |
Gene Type | protein-coding |
Description | SH2 domain containing 4A |
Other Description | SH2 domain-containing protein 4A|protein SH(2)A|protein phosphatase 1 regulatory subunit 38|protein phosphatase 1, regulatory subunit 38 |
Swissprots | Q5XKC1 B4DDR1 Q9H7F7 Q6NXE9 Q96C88 Q86YM2 Q9H788 |
Accessions | EAW63773 Q9H788 AK024620 BAB14935 AK024799 BAB15010 AK225052 AK293301 BAG56822 AY190323 AAO41715 BC014525 AAH14525 BC067117 AAH67117 BC082982 AAH82982 CA418381 DA952240 XM_011544610 XP_011542912 XM_011544611 XP_011542913 NM_001174159 NP_001167630 NM_001174160 NP_001167631 NM_022071 NP_071354 |
Function | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269|PubMed:12476414}. |
SH2D4A CRISPR/Cas9 KO Plasmid (h) - sc-406597 from Santa Cruz Biotechnology
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SH2D4A HDR Plasmid (h) - sc-406597-HDR from Santa Cruz Biotechnology
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SH2D4A Double Nickase Plasmid (h) - sc-406597-NIC from Santa Cruz Biotechnology
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SH2D4A Double Nickase Plasmid (h2) - sc-406597-NIC-2 from Santa Cruz Biotechnology
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SH2D4A CRISPR Activation Plasmid (h) - sc-406597-ACT from Santa Cruz Biotechnology
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SH2D4A CRISPR Activation Plasmid (h2) - sc-406597-ACT-2 from Santa Cruz Biotechnology
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SH2D4A Lentiviral Activation Particles (h) - sc-406597-LAC from Santa Cruz Biotechnology
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SH2D4A Lentiviral Activation Particles (h2) - sc-406597-LAC-2 from Santa Cruz Biotechnology
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SH2D4A siRNA (h) - sc-77685 from Santa Cruz Biotechnology
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SH2D4A shRNA Plasmid (h) - sc-77685-SH from Santa Cruz Biotechnology
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SH2D4A shRNA (h) Lentiviral Particles - sc-77685-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU047501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19252 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19252 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09007 from Sigma-Aldrich
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SH2D4A siRNA (Human) - CRJ1850 from Cohesion Biosciences
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SH2D4A RNAi - H00063898-R01 from Novus Biologicals
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SH2D4A - MBS8226258 from MyBioSource
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Human SH2D4A siRNA - orb272351 from Biorbyt
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SH2D4A shRNA Plasmid (Human) - CHJ1850 from Cohesion Biosciences
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SH2D4A miRNA 3'UTR clone - MiUTR3H-16063 from Creative biogene
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