MTUS1

Gene Symbol	MTUS1
Entrez Gene	57509
Alt Symbol	ATBP, ATIP, ICIS, MP44, MTSG1
Species	Human
Gene Type	protein-coding
Description	microtubule associated tumor suppressor 1
Other Description	AT2 receptor-binding protein|AT2 receptor-interacting protein|AT2R binding protein|angiotensin-II type 2 receptor-interacting protein|erythroid differentiation-related|microtubule-associated tumor suppressor 1|mitochondrial tumor suppressor gene 1|transcription factor MTSG1
Swissprots	Q6URW7 Q9ULD2 Q9H7T2 Q8WTT9 Q8N4M6 Q6PK49 B4DH03 B3KWJ9 Q659F4 Q63HJ6 A8K135 B9EGA1 D3DSP8 B2RBJ6
Accessions	CAC60396 CAC60397 EAW63804 EAW63805 EAW63806 EAW63807 EAW63808 EAW63809 EAW63810 Q9ULD2 AB033114 BAA86602 AF086371 AF121259 AAG33674 AF293357 AAL37035 AF394227 AK000172 AK024357 BAB14894 AK026661 AK093875 AK125188 BAG54161 AK289750 BAF82439 AK294860 BAG57964 AK304105 BAG65008 AK310871 AK314692 BAG37243 AL096842 CAB50791 AY363099 AAQ24172 BC007328 AAH07328 BC017740 BC033842 AAH33842 BC098381 BC117564 BC136320 AAI36321 BC140067 AAI40068 BC140068 AAI40069 BC142971 AAI42972 BC171765 BX648879 CAH56128 DA075758 DA113649 DA339588 DB221458 FJ458440 FJ458441 FJ472826 FJ472827 XM_005273577 XP_005273634 XM_005273578 XP_005273635 XM_005273579 XP_005273636 XM_005273580 XP_005273637 XM_005273581 XP_005273638 XM_005273582 XP_005273639 XM_005273583 XP_005273640 XM_011544595 XP_011542897 XR_247126 NM_001001924 NP_001001924 NM_001001925 NP_001001925 NM_001001931 NP_001001931 NM_001166393 NP_001159865 NM_020749 NP_065800 NM_001001927
Function	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain. {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:15123706, ECO:0000269|PubMed:16270321, ECO:0000269|PubMed:16887298, ECO:0000269|PubMed:16969489, ECO:0000269|PubMed:17656251}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTUS1 full length protein - ab163572 from Abcam Category Protein Source Wheat germ Species Human

MTUS1 Antibody Blocking Peptide - LS-E16313 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MTUS1 Antibody Blocking Peptide - LS-E16312 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MTUS1 Protein - H00057509-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MTUS1 Blocking Peptide - 33R-7629 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MTUS1 Blocking Peptide - 33R-4631 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MTUS1 - H00057509-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

MTUS1 fusion protein - ag5605 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MTUS1 fusion protein - Ag4242 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Microtubule-associated tumor suppressor 1(MTUS1) ,partial - CSB-YP892343HU CSB-EP892343HU CSB-BP892343HU CSB-MP892343HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MTUS1 Protein - abx163425 from Abbexa Category Protein Species Human, Mouse, Rat

Recombinant Mitochondrial Tumor Suppressor 1 (MTUS1) - RPC635Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mitochondrial Tumor Suppressor 1 (MTUS1) - RPC635Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mitochondrial Tumor Suppressor 1 (MTUS1) - RPC635Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Mitochondrial Tumor Suppressor 1 (MTUS1) - RPC635Hu01 from Cloud-clone Category Protein Source E.coli Species Human

MTUS1-Blocking-Peptide-N-Term - BP22015a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MTUS1-Blocking-Peptide-C-Term - BP22012b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MTUS1 Peptide, Human - M34GP09922H from Creative Peptides Category Peptide Source Synthetic. Species Human

MTUS1 Recombinant Protein (OPCD00603) - OPCD00603 from Aviva Systems Biology Category Protein Source E.coli Species Human

MTUS1 Recombinant Protein Antigen - NBP2-57208PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MTUS1 Recombinant Protein Antigen - NBP2-57447PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Microtubule-associated tumor suppressor 1 (MTUS1), partial, Recombinant Protein - MBS1366528 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Mitochondrial Tumor Suppressor 1, Recombinant Protein - MBS2033166 from MyBioSource Category Protein Prices $170.00, $350.00, $545.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Mitochondrial Tumor Suppressor 1, Recombinant Protein - MBS2032992 from MyBioSource Category Protein Prices $185.00, $380.00, $585.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Mitochondrial Tumor Suppressor 1, Recombinant Protein - MBS2033586 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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