MTUS1

Gene Symbol MTUS1
Entrez Gene 57509
Alt Symbol ATBP, ATIP, ICIS, MP44, MTSG1
Species Human
Gene Type protein-coding
Description microtubule associated tumor suppressor 1
Other Description AT2 receptor-binding protein|AT2 receptor-interacting protein|AT2R binding protein|angiotensin-II type 2 receptor-interacting protein|erythroid differentiation-related|microtubule-associated tumor suppressor 1|mitochondrial tumor suppressor gene 1|transcription factor MTSG1
Swissprots Q6URW7 Q9ULD2 Q9H7T2 Q8WTT9 Q8N4M6 Q6PK49 B4DH03 B3KWJ9 Q659F4 Q63HJ6 A8K135 B9EGA1 D3DSP8 B2RBJ6
Accessions CAC60396 CAC60397 EAW63804 EAW63805 EAW63806 EAW63807 EAW63808 EAW63809 EAW63810 Q9ULD2 AB033114 BAA86602 AF086371 AF121259 AAG33674 AF293357 AAL37035 AF394227 AK000172 AK024357 BAB14894 AK026661 AK093875 AK125188 BAG54161 AK289750 BAF82439 AK294860 BAG57964 AK304105 BAG65008 AK310871 AK314692 BAG37243 AL096842 CAB50791 AY363099 AAQ24172 BC007328 AAH07328 BC017740 BC033842 AAH33842 BC098381 BC117564 BC136320 AAI36321 BC140067 AAI40068 BC140068 AAI40069 BC142971 AAI42972 BC171765 BX648879 CAH56128 DA075758 DA113649 DA339588 DB221458 FJ458440 FJ458441 FJ472826 FJ472827 XM_005273577 XP_005273634 XM_005273578 XP_005273635 XM_005273579 XP_005273636 XM_005273580 XP_005273637 XM_005273581 XP_005273638 XM_005273582 XP_005273639 XM_005273583 XP_005273640 XM_011544595 XP_011542897 XR_247126 NM_001001924 NP_001001924 NM_001001925 NP_001001925 NM_001001931 NP_001001931 NM_001166393 NP_001159865 NM_020749 NP_065800 NM_001001927
Function Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain. {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:15123706, ECO:0000269|PubMed:16270321, ECO:0000269|PubMed:16887298, ECO:0000269|PubMed:16969489, ECO:0000269|PubMed:17656251}.

MTUS1 (A-4) - sc-393120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MTUS1 (A-4): sc-393120. Western blot analysis of MTUS1 expression in non-transfected: sc-117752 (A) and human MTUS1 transfected: sc-115006 (B) 293T whole cell lysates.

MTUS1 (E-8) - sc-393121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MTUS1 (E-8): sc-393121. Western blot analysis of MTUS1 expression in non-transfected: sc-117752 (A) and human MTUS1 transfected: sc-115006 (B) 293T whole cell lysates.

MTUS1 (H-300) - sc-366608 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MTUS1 (Q-16) - sc-98018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MTUS1 (Q-16): sc-98018. Western blot analysis of MTUS1 expression in non-transfected: sc-117752 (A) and human MTUS1 transfected: sc-115006 (B) 293T whole cell lysates.

MTUS1 (T-12) - sc-98019 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MTUS1 (T-12): sc-98019. Western blot analysis of MTUS1 expression in non-transfected: sc-117752 (A) and human MTUS1 transfected: sc-115006 (B) 293T whole cell lysates.

MTUS1 (31-Y) - sc-100293 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MTUS1 (31-Y): sc-100293. Western blot analysis of MTUS1 expression in non-transfected: sc-117752 (A) and human MTUS1 transfected: sc-115006 (B) 293T whole cell lysates.

Anti-MTUS1 antibody - ab198176 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue labeling MTUS1 using ab198176 at a 1/40 dilution.

Anti-MTUS1 antibody - ab57477 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HeLa cells stained with ab57477 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab57477, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-MTUS1 antibody - ab113979 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab113979, used for IP at 3 µg/mg lysate, staining MTUS1 in HeLa whole cell lysate (1 mg for IP, 20% of IP loaded). Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-MTUS1 Antibody (aa450-500) - LS-C289156 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MTUS1 Antibody (aa1-241, Azide-free) - LS-C327816 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-MTUS1 Antibody (aa1220-1270) - LS-C289158 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MTUS1 Antibody (aa90-139) - LS-C40475 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-MTUS1 Antibody (C-Terminus) - LS-C110942 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MTUS1 antibody LS-C110942 Western blot of HeLa lysate.

MTUS1 Antibody - NBP1-60099 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MTUS1 Antibody [NBP1-60099] - Sample Type: Human Fetal Lung Antibody Dilution: 1.0 ug/ml

MTUS1 Antibody - NBP1-60097 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MTUS1 Antibody [NBP1-60097] - Titration: 1.25ug/ml Positive Control: Jurkat cell lysate.

MTUS1 Antibody (1C7) - H00057509-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C7

MTUS1 Antibody (1C10) - H00057509-M02A from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 1C10

MTUS1 Polyclonal Antibody - bs-6076R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-MTUS1 Polyclonal Antibody, Unconjugated (bs-6076R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Monoclonal Anti-MTUS1 antibody produced in mouse - WH0057509M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C7
<B>Immunoblotting</B><BR/>Monoclonal Anti-MTUS1, <B>Cat. No. WH0057509M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~27.7 kDa using K-562 lysate.

Anti-MTUS1 antibody produced in rabbit - SAB2101526 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MTUS1: <B>Cat. No.SAB2101526</B>: MTUS1 in HeLa cell lysate with MTUS1 antibody at 1.0 μg/mL.

Monoclonal Anti-MTUS1 antibody produced in mouse - SAB1405213 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1C10
<B>Immunoblotting</B><BR/>Monoclonal Anti-MTUS1: <B>Cat. No. SAB1405213</B>: Antibody concentration: 1 μg/mL. Specific band of ~52.5 kDa using immunogen protein lysate.

Anti-MTUS1 antibody produced in rabbit - AV44418 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV44418</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat

MTUS1 antibody - N-terminal region (ARP44418_T100) - ARP44418_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MTUS1 antibody - middle region (ARP44419_P050) - ARP44419_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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