PIK3C2A

Gene Symbol PIK3C2A
Entrez Gene 5286
Alt Symbol CPK, PI3-K-C2(ALPHA), PI3-K-C2A
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Other Description C2-containing phosphatidylinositol kinase|PI3K-C2-alpha|PI3K-C2alpha|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphoinositide 3-kinase-C2-alpha|phosphoinositide-3-kinase, class 2, alpha polypeptide|ptdIns-3-kinase C2 subunit alpha
Swissprots O00443 B4E2G4 Q14CQ9 B0LPH2
Accessions ABY87551 AGC09601 CAB69383 EAW68447 O00443 AK294416 BAG57666 AK299474 BAG61438 AK304262 BAG65126 AK309610 AK310248 AL049998 AL832699 BC031681 BC035982 BC040952 BC113658 AAI13659 BX648778 HQ258691 ADR83442 Y13367 CAA73797 XM_005252977 XP_005253034 XM_005252978 XP_005253035 XM_005252980 XP_005253037 XM_011520186 XP_011518488 XM_011520187 XP_011518489 NM_002645 NP_002636
Function Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on lar
Subcellular Location Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic.
Tissue Specificity Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:21127054, ECO:0000269|PubMed:9337861}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

PI3 Kinase Class II α (D3Q5B) Rabbit mAb - 12402 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Q5B
Western blot analysis of extracts from SW620 and HeLa cells using PI3 Kinase Class II α (D3Q5B) Rabbit mAb.

PI-3 kinase C2α (C-19) - sc-48637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase C2α (C-19): sc-48637. Western blot analysis of PI 3-kinase C2α expression in rat brain tissue extract.

PI-3 kinase C2α (E-19) - sc-48638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 3-kinase C2α (G-5) - sc-365290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 3-kinase C2α (G-5): sc-365290. Western blot analysis of PI 3-kinase C2α expression in HeLa whole cell lysate.

PI 3-kinase C2α (H-300) - sc-67306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase C2α (H-300): sc-67306. Western blot analysis of PI 3-kinase C2α expression in HeLa (A), Jurkat (B) and IMR-32 (C) whole cell lysates.

PI 3-kinase C2α (N-15) - sc-48639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 3-kinase C2α (17) - sc-136298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PI 3-kinase C2α (17): sc-136298. Western blot analysis of PI 3-kinase C2α expression in rat brain tissue extract.

Anti-PI 3 Kinase Class 2A antibody - ab5448 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PI 3 Kinase Class 2A antibody [2C2] - ab170320 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C2
Immunohistochemical analysis of paraffin-embedded adenocarcinoma of Human endometrium tissue labeling PI 3 Kinase Class 2A with ab170320 at 1/150 dilution.

Anti-PI 3 Kinase Class 2A antibody [3E7] - ab125087 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3E7
ab125087, at 5 µg/ml, staining PI 3 Kinase Class 2A in Formalin-fixed, Paraffin-embedded Human capillaries tissue by Immunohistochemistry.

Anti-PI 3 Kinase Class 2A antibody - C-terminal - ab154583 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase Class 2A antibody - C-terminal (ab154583) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-PIK3C2A Antibody (aa230-560, clone 3H2) - LS-C336382 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H2
IHC of paraffin-embedded Human pancreas tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 2F10) - LS-C336388 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F10
E.coli lysate (left lane) and E.coli lysate expressing human recombinant protein fragment corresponding to amino acids 230-560 of human PIK3C2A (NP_002636) were separated by SDS-PAGE and immunoblotted with anti-PIK3C2A.

Anti-PIK3C2A Antibody (aa230-560, clone 2B5) - LS-C336387 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B5
E.coli lysate (left lane) and E.coli lysate expressing human recombinant protein fragment corresponding to amino acids 230-560 of human PIK3C2A (NP_002636) were separated by SDS-PAGE and immunoblotted with anti-PIK3C2A.

Anti-PIK3C2A Antibody (aa230-560, clone 3F8) - LS-C336371 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F8
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 2C2) - LS-C336367 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C2
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 2C10) - LS-C336378 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C10
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 3D9) - LS-C336384 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D9
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 1B8) - LS-C336386 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B8
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 11D6) - LS-C336390 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11D6
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 15H1) - LS-C336381 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 15H1
IHC of paraffin-embedded Human tonsil using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 4H9) - LS-C336385 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 2C11) - LS-C336391 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C11
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 4E6) - LS-C336389 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E6
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PIK3C2A Antibody (aa230-560, clone 2E4) - LS-C336394 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E4
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3C2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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