PIK3C2A

Gene Symbol	PIK3C2A
Entrez Gene	5286
Alt Symbol	CPK, PI3-K-C2(ALPHA), PI3-K-C2A
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Other Description	C2-containing phosphatidylinositol kinase|PI3K-C2-alpha|PI3K-C2alpha|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphoinositide 3-kinase-C2-alpha|phosphoinositide-3-kinase, class 2, alpha polypeptide|ptdIns-3-kinase C2 subunit alpha
Swissprots	O00443 B4E2G4 Q14CQ9 B0LPH2
Accessions	ABY87551 AGC09601 CAB69383 EAW68447 O00443 AK294416 BAG57666 AK299474 BAG61438 AK304262 BAG65126 AK309610 AK310248 AL049998 AL832699 BC031681 BC035982 BC040952 BC113658 AAI13659 BX648778 HQ258691 ADR83442 Y13367 CAA73797 XM_005252977 XP_005253034 XM_005252978 XP_005253035 XM_005252980 XP_005253037 XM_011520186 XP_011518488 XM_011520187 XP_011518489 NM_002645 NP_002636
Function	Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on lar
Subcellular Location	Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic.
Tissue Specificity	Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:21127054, ECO:0000269|PubMed:9337861}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PIK3C2A ELISA Kit (Sandwich ELISA) - LS-F4163 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human CPK ELISA Kit - HC0817 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CPK ELISA Kit - AC0817 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

ELISA Kit for Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide (PIK3C2a) - SEA383Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha, ELISA Kit - MBS283424 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide (PIK3C2a), ELISA Kit - MBS2022004 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.057ng/mL. Range 0.156-10ng/mL

Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide (PIK3C2a), ELISA Kit - MBS2000095 from MyBioSource Category ELISA Kit Prices $345.00, $505.00, $655.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 1.6 U/L. Range 3.125-200 U/L The standard curve concentrations used for the ELISA's were 200 U/L, 100 U/L, 50 U/L, 25 U/L, 12.5 U/L, 6.25 U/L, 3.125 U/L

PI 3-Kinase Class II HTRF Assay - 33-039 from EMD Millipore

PI 3-Kinase Class II HTRF Assay - 33-038 from EMD Millipore

Rat PIK3C2A ELISA Kit (Sandwich ELISA) - LS-F21586 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Human PIK3C2A ELISA Kit (Sandwich ELISA) - LS-F20663 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 3.125 Range 0.156-10 ng/ml

Human PIK3C2a ELISA Kit - orb364945 from Biorbyt Category ELISA Kit Prices $510.00, $578.00 Sizes 48 test, 96 test Range Detection Range: 3.125-200 U/L Detection low threshold: 1.6 U/L

Human PIK3C2a ELISA Kit - abx575358 from Abbexa Category ELISA Kit Sensitivity 1.6 U/L Range 3.125 U/l - 200 U/l

Human CPK ELISA Kit - E010205 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

Human PIK3C2A ELISA Kit - E029125 from Biobool Category ELISA Kit Sensitivity Typically less than 1.6 U/L.

Human CPK ELISA Kit - EHC0817 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

anti-PIK3C2A antibody - ARG63599 from Arigo Biolaboratories Category ELISA Kit

Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide, ELISA Kit - MBS764695 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875mU/ml Range 3.125-200mIU/ml

Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide (PIK3C2a), ELISA Kit - MBS456125 from MyBioSource Category ELISA Kit Prices $390.00, $510.00, $2,225.00, $4,320.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <1.6U/L Range 3.125-200U/L

Phosphoinositide-3-Kinase Class-2-Alpha Polypeptide (PI3K2A), ELISA Kit - MBS9376066 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PIK3C2A ELISA Kit (CLIA) - LS-F30058 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.375 mU/ml Range 0.156-10 ng/ml

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