| Gene Symbol | PIK3C2A |
|---|---|
| Entrez Gene | 5286 |
| Alt Symbol | CPK, PI3-K-C2(ALPHA), PI3-K-C2A |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
| Other Description | C2-containing phosphatidylinositol kinase|PI3K-C2-alpha|PI3K-C2alpha|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphoinositide 3-kinase-C2-alpha|phosphoinositide-3-kinase, class 2, alpha polypeptide|ptdIns-3-kinase C2 subunit alpha |
| Swissprots | O00443 B4E2G4 Q14CQ9 B0LPH2 |
| Accessions | ABY87551 AGC09601 CAB69383 EAW68447 O00443 AK294416 BAG57666 AK299474 BAG61438 AK304262 BAG65126 AK309610 AK310248 AL049998 AL832699 BC031681 BC035982 BC040952 BC113658 AAI13659 BX648778 HQ258691 ADR83442 Y13367 CAA73797 XM_005252977 XP_005253034 XM_005252978 XP_005253035 XM_005252980 XP_005253037 XM_011520186 XP_011518488 XM_011520187 XP_011518489 NM_002645 NP_002636 |
| Function | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on lar |
| Subcellular Location | Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic. |
| Tissue Specificity | Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:21127054, ECO:0000269|PubMed:9337861}. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
PI 3-kinase C2α CRISPR/Cas9 KO Plasmid (h) - sc-402567 from Santa Cruz Biotechnology
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PI 3-kinase C2α HDR Plasmid (h) - sc-402567-HDR from Santa Cruz Biotechnology
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PI 3-kinase C2α Double Nickase Plasmid (h) - sc-402567-NIC from Santa Cruz Biotechnology
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PI 3-kinase C2α Double Nickase Plasmid (h2) - sc-402567-NIC-2 from Santa Cruz Biotechnology
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PI 3-kinase C2α CRISPR Activation Plasmid (h) - sc-402567-ACT from Santa Cruz Biotechnology
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PI 3-kinase C2α CRISPR Activation Plasmid (h2) - sc-402567-ACT-2 from Santa Cruz Biotechnology
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PI 3-kinase C2α Lentiviral Activation Particles (h) - sc-402567-LAC from Santa Cruz Biotechnology
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PI 3-kinase C2α Lentiviral Activation Particles (h2) - sc-402567-LAC-2 from Santa Cruz Biotechnology
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PI 3-kinase C2α siRNA (h) - sc-61340 from Santa Cruz Biotechnology
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PI 3-kinase C2α shRNA Plasmid (h) - sc-61340-SH from Santa Cruz Biotechnology
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PI 3-kinase C2α shRNA (h) Lentiviral Particles - sc-61340-V from Santa Cruz Biotechnology
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PIK3C2A RNAi - H00005286-R02 from Novus Biologicals
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MISSION® esiRNA - EHU020941 from Sigma-Aldrich
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MISSION® siRNA - SIHK1641 from Sigma-Aldrich
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MISSION® siRNA - SIHK1642 from Sigma-Aldrich
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MISSION® siRNA - SIHK1640 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1355 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1355 from Sigma-Aldrich
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PIK3C2A siRNA (Human) - CRH3531 from Cohesion Biosciences
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shRNA set against Human PIK3C2A (NM_002645.2) - SHH375664 from Creative biogene
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shRNA set against Human PIK3C2A(NM_002645.2) - SHR104550 from Creative biogene
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Human PIK3C2A siRNA - orb264033 from Biorbyt
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PIK3C2A shRNA Plasmid (Human) - CHH3531 from Cohesion Biosciences
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PIK3C2A miRNA 3'UTR clone - MiUTR1H-07903 from Creative biogene
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