| Gene Symbol |
FSCN1
|
| Entrez Gene |
6624
|
| Alt Symbol |
FAN1, HSN, SNL, p55
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fascin actin-bundling protein 1
|
| Other Description |
55 kDa actin-bundling protein|fascin|fascin homolog 1, actin-bundling protein|singed-like (fascin homolog, sea urchin)
|
| Swissprots |
Q9BRF1 B2RE97 Q96IH1 A6NI89 Q96IC5 Q16658
|
| Accessions |
AAL01526 CBX47601 EAW87344 EAW87345 EAW87346 Q16658 AK095254 BAG53015 AK095830 BAG53141 AK125295 AK316607 BAG38194 BC000521 AAH00521 BC006304 AAH06304 BC007539 AAH07539 BC007643 AAH07643 BC007948 AAH07948 BC007988 AAH07988 BI546742 BT006636 AAP35282 BU629782 DQ891402 ABM82328 DQ894580 ABM85506 U03057 AAA86442 U09873 AAA62201 NM_003088 NP_003079
|
| Function |
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
MicroRNAs in cancer
|
![Western Blot: Fascin Overexpression Lysate (Adult Normal) [NBL1-10841] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Fascin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3753_Fascin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10841-img0002.jpg)