Gene Symbol | FSCN1 |
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Entrez Gene | 6624 |
Alt Symbol | FAN1, HSN, SNL, p55 |
Species | Human |
Gene Type | protein-coding |
Description | fascin actin-bundling protein 1 |
Other Description | 55 kDa actin-bundling protein|fascin|fascin homolog 1, actin-bundling protein|singed-like (fascin homolog, sea urchin) |
Swissprots | Q9BRF1 B2RE97 Q96IH1 A6NI89 Q96IC5 Q16658 |
Accessions | AAL01526 CBX47601 EAW87344 EAW87345 EAW87346 Q16658 AK095254 BAG53015 AK095830 BAG53141 AK125295 AK316607 BAG38194 BC000521 AAH00521 BC006304 AAH06304 BC007539 AAH07539 BC007643 AAH07643 BC007948 AAH07948 BC007988 AAH07988 BI546742 BT006636 AAP35282 BU629782 DQ891402 ABM82328 DQ894580 ABM85506 U03057 AAA86442 U09873 AAA62201 NM_003088 NP_003079 |
Function | Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
Subcellular Location | Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol. |
Tissue Specificity | Ubiquitous. |
Top Pathways | MicroRNAs in cancer |
Fascin peptide - ab107112 from Abcam
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Human Fascin full length protein - ab176620 from Abcam
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Human Fascin full length protein - ab99240 from Abcam
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FSCN1 / Fascin Antibody Blocking Peptide - LS-E8426 from LifeSpan Bioscience
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FSCN1 / Fascin Antibody Blocking Peptide - LS-E16798 from LifeSpan Bioscience
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Recombinant Human Fascin Protein - NBP1-45313 from Novus Biologicals
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Fascin Recombinant Protein - P3409 from Novus Biologicals
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Fascin-Antibody-Center-Blocking-Peptide - BP6736c from Abgent, a WuXi AppTec company
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Fascin-Antibody-N-term-Blocking-Peptide - BP6736a from Abgent, a WuXi AppTec company
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FSCN1 Protein (OPPA02469) - OPPA02469 from Aviva Systems Biology
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Human FSCN1 protein - orb81127 from Biorbyt
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FSCN1 peptide - orb72700 from Biorbyt
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Fscn1 Blocking Peptide - 33R-9865 from Fitzgerald
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FSCN1 protein (His tag) - 80R-1424 from Fitzgerald
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Human Fascin Protein - abx066499 from Abbexa
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Fascin Peptide - AC21-2810-P from Abcore
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Fascin (1-493, His-tag) - AR09600PU-L from Acris Antibodies
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Fascin (1-493, His-tag) - AR09600PU-N from Acris Antibodies
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Fascin - P3409 from Acris Antibodies
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Recombinant Human Fascin - 228-13102-1 from RayBiotech
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Recombinant Human Fascin - 228-13102-2 from RayBiotech
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Recombinant Human Fascin - 228-13102-3 from RayBiotech
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Fascin (FSCN), Human - 20-7987 from ARP American Research Products
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FSCN1, 1-493aa, Human, His tag, E.coli - 01-1906-1 from ARP American Research Products
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Fascin fusion protein - Ag6074 from Proteintech Group
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