Gene Symbol | GALNT3 |
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Entrez Gene | 2591 |
Alt Symbol | GalNAc-T3, HFTC, HHS |
Species | Human |
Gene Type | protein-coding |
Description | polypeptide N-acetylgalactosaminyltransferase 3 |
Other Description | GalNAc transferase 3|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)|polypeptide GalNAc transferase 3|polypeptide GalNAc-transferase T3|pp-GaNTase 3|protein-UDP acetylgalactosaminyltransferase 3 |
Swissprots | Q53TG9 Q7Z476 Q14435 |
Accessions | AAY14678 EAX11323 EAX11324 Q14435 AJ505954 CAD44536 AK307391 AK313389 BAG36187 BC056246 AAH56246 BC113565 AAI13566 BC113567 AAI13568 BU567493 BX094158 BX647473 DB098143 DB727693 HQ258332 ADR83086 X92689 CAA63371 XM_005246449 XP_005246506 XM_006712402 XP_006712465 XM_011510929 XP_011509231 NM_004482 NP_004473 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. {ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:9295285}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. |
Tissue Specificity | Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney. {ECO:0000269|PubMed:12708471, ECO:0000269|PubMed:8663203}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T3 CRISPR/Cas9 KO Plasmid (h) - sc-407682 from Santa Cruz Biotechnology
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GalNAc-T3 HDR Plasmid (h) - sc-407682-HDR from Santa Cruz Biotechnology
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GalNAc-T3 Double Nickase Plasmid (h) - sc-407682-NIC from Santa Cruz Biotechnology
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GalNAc-T3 Double Nickase Plasmid (h2) - sc-407682-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T3 CRISPR Activation Plasmid (h) - sc-407682-ACT from Santa Cruz Biotechnology
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GalNAc-T3 CRISPR Activation Plasmid (h2) - sc-407682-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T3 Lentiviral Activation Particles (h) - sc-407682-LAC from Santa Cruz Biotechnology
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GalNAc-T3 Lentiviral Activation Particles (h2) - sc-407682-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T3 siRNA (h) - sc-75096 from Santa Cruz Biotechnology
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GalNAc-T3 shRNA Plasmid (h) - sc-75096-SH from Santa Cruz Biotechnology
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GalNAc-T3 shRNA (h) Lentiviral Particles - sc-75096-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9108 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9108 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07710 from Sigma-Aldrich
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GALNT3 siRNA (Human) - CRH1726 from Cohesion Biosciences
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Polypeptide GalNac Transferase 3/GALNT3 RNAi - H00002591-R01 from Novus Biologicals
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GALNT3 - MBS8239833 from MyBioSource
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shRNA set against Human GALNT3 (NM_004482.3) - SHH299041 from Creative biogene
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shRNA set against Human GALNT3(NM_004482.3) - SHH076259 from Creative biogene
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Human GALNT3 siRNA - orb262228 from Biorbyt
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GALNT3 shRNA Plasmid (Human) - CHH1726 from Cohesion Biosciences
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GALNT3 miRNA 3'UTR clone - MiUTR1H-03939 from Creative biogene
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