| Gene Symbol |
Grm2
|
| Entrez Gene |
108068
|
| Alt Symbol |
4930441L02Rik, Gprc1b, mGluR2, mGluR7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 2
|
| Other Description |
G protein coupled receptor, family C, group 1, member B|G protein-coupled receptor, family C, group 1, member B|metabotropic glutamate receptor 2
|
| Swissprots |
Q14BI2
|
| Accessions |
EDL21160 Q14BI2 AK015353 AK034263 AK046803 AY255603 AAO85115 BC115866 AAI15867 BQ174642 BY290719 CK619406 NM_001160353 NP_001153825
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:23129762}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
|
| Tissue Specificity |
Detected in neurons in brain cortex (at protein level). {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:23129762}.
|
| Top Pathways |
Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction
|