Gene Symbol | Grm2 |
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Entrez Gene | 108068 |
Alt Symbol | 4930441L02Rik, Gprc1b, mGluR2, mGluR7 |
Species | Mouse |
Gene Type | protein-coding |
Description | glutamate receptor, metabotropic 2 |
Other Description | G protein coupled receptor, family C, group 1, member B|G protein-coupled receptor, family C, group 1, member B|metabotropic glutamate receptor 2 |
Swissprots | Q14BI2 |
Accessions | EDL21160 Q14BI2 AK015353 AK034263 AK046803 AY255603 AAO85115 BC115866 AAI15867 BQ174642 BY290719 CK619406 NM_001160353 NP_001153825 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:23129762}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. |
Tissue Specificity | Detected in neurons in brain cortex (at protein level). {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:23129762}. |
Top Pathways | Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction |
mGluR-2 CRISPR/Cas9 KO Plasmid (m) - sc-430795 from Santa Cruz Biotechnology
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mGluR-2 HDR Plasmid (m) - sc-430795-HDR from Santa Cruz Biotechnology
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mGluR-2 Double Nickase Plasmid (m) - sc-430795-NIC from Santa Cruz Biotechnology
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mGluR-2 Double Nickase Plasmid (m2) - sc-430795-NIC-2 from Santa Cruz Biotechnology
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mGluR-2 CRISPR Activation Plasmid (m) - sc-430795-ACT from Santa Cruz Biotechnology
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mGluR-2 CRISPR Activation Plasmid (m2) - sc-430795-ACT-2 from Santa Cruz Biotechnology
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mGluR-2 Lentiviral Activation Particles (m) - sc-430795-LAC from Santa Cruz Biotechnology
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mGluR-2 Lentiviral Activation Particles (m2) - sc-430795-LAC-2 from Santa Cruz Biotechnology
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mGluR-2 siRNA (m) - sc-61029 from Santa Cruz Biotechnology
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mGluR-2 shRNA Plasmid (m) - sc-61029-SH from Santa Cruz Biotechnology
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mGluR-2 shRNA (m) Lentiviral Particles - sc-61029-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU199441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32862 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32862 from Sigma-Aldrich
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GRM2 siRNA (Mouse) - CRN0899 from Cohesion Biosciences
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GRM2 - MBS8240968 from MyBioSource
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shRNA set against Mouse GRM2 (NM_001160353.1) - SHH308106 from Creative biogene
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Mouse GRM2 siRNA - orb290374 from Biorbyt
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GRM2 shRNA Plasmid (Mouse) - CHN0899 from Cohesion Biosciences
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