Gene Symbol | NR2E1 |
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Entrez Gene | 7101 |
Alt Symbol | TLL, TLX, XTLL |
Species | Human |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 2, group E, member 1 |
Other Description | nuclear receptor TLX|nuclear receptor subfamily 2 group E member 1|protein tailless homolog|tailes-related receptor|tailless homolog |
Swissprots | Q9Y466 Q6ZMP8 |
Accessions | EAW48385 EAW48386 Q9Y466 AB307709 BAH02300 AF220532 AAG31945 AF411525 AAL05871 AK131541 BAD18677 BC028031 AAH28031 DA806924 HQ692846 ADZ17357 Y13276 CAA73725 XM_011536094 XP_011534396 NM_001286102 NP_001273031 NM_003269 NP_003260 |
Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells. {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. {ECO:0000269|PubMed:9628820}. |
NR2E1 / TLX Antibody Blocking Peptide - LS-E11804 from LifeSpan Bioscience
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NR2E1 / TLX Antibody Blocking Peptide - LS-E11215 from LifeSpan Bioscience
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NR2E1 / TLX Antibody Blocking Peptide - LS-E28564 from LifeSpan Bioscience
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Recombinant Human TLX/NR2E1 Protein - H00007101-Q01 from Novus Biologicals
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TLX/NR2E1 Recombinant Protein - H00007101-P01 from Novus Biologicals
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NR2E1 Blocking Peptide - 33R-4758 from Fitzgerald
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NR2E1 - H00007101-P01 from Acris Antibodies
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NR2E1 - H00007101-P01-10 from Acris Antibodies
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NR2E1 - H00007101-Q01-10 from Acris Antibodies
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NR2E1 - H00007101-Q01-25 from Acris Antibodies
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NR2E1 fusion protein - ag4261 from Proteintech Group
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Recombinant Oryzias latipes Nuclear receptor subfamily 2 group E member 1(nr2e1 - CSB-YP897414OFH CSB-EP897414OFH CSB-BP897414OFH CSB-MP897414OFH from Cusabio
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NR2E1 Protein - abx164363 from Abbexa
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TLX/NR2E1 Recombinant Protein Antigen - NBP2-38764PEP from Novus Biologicals
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NR2E1-Blocking-Peptide-Center - BP19904c from Abgent, a WuXi AppTec company
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NR2E1 Peptide, Human - M34GP10595H from Creative Peptides
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Nuclear receptor subfamily 2 group E member 1 (nr2e1), Recombinant Protein - MBS1457876 from MyBioSource
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