TIMP1

Gene Symbol TIMP1
Entrez Gene 7076
Alt Symbol CLGI, EPA, EPO, HCI, TIMP
Species Human
Gene Type protein-coding
Description TIMP metallopeptidase inhibitor 1
Other Description TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Swissprots P01033 Q9UCU1 Q14252
Accessions AAA75558 AAX47478 BAA01913 CAR95107 CAS92765 CBX47572 EAW59315 EAW59316 P01033 A10416 CAA00898 AK074854 BAG52016 AK296116 BAG58865 AK307222 AK310206 AK311937 BAG34878 BC000866 AAH00866 BC007097 BQ181804 BU857950 CR407638 CAG28566 CR541982 CAG46779 DQ891122 ABM82048 DQ894301 ABM85227 M12670 AAA52436 M59906 AAA63234 S68252 AAD14009 X02598 CAA26443 X03124 CAA26902 XM_005272645 XP_005272702 NM_003254 NP_003245
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|P
Subcellular Location Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
Tissue Specificity Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.

TIMP1 (D10E6) Rabbit mAb - 8946 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10E6
Western blot analysis of extracts from various cell lines using TIMP1 (D10E6) Rabbit mAb.

TIMP-1 (2A5) - sc-21734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIMP-1 (2A5): sc-21734. Western blot analysis of human recombinant TIMP-1.

TIMP-1 (C-20) - sc-6832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIMP-1 (C-20): sc-6832. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic and membrane staining of glandular cells.

TIMP-1 (G-6) - sc-365905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIMP-1 (G-6): sc-365905. Western blot analysis of human recombinant TIMP-1.

TIMP-1 (H-150) - sc-5538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIMP-1 (H-150): sc-5538. Western blot analysis of human recombinant TIMP-1 fusion protein.

TIMP-1 (SPM355) - sc-56489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
TIMP-1 (SPM355): sc-56489. Western blot analysis of TIMP-1 expression in non-transfected: sc-117752 (A) and human TIMP-1 transfected: sc-110547 (B) 293T whole cell lysates.

TIMP-1 (102D1) - sc-58435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
TIMP-1 (102D1): sc-58435. Western blot analysis of TIMP-1 expression in non-transfected: sc-117752 (A) and human TIMP-1 transfected: sc-110547 (B) 293T whole cell lysates.

Anti-TIMP1 antibody - ab61224 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIMP1 antibody (ab61224) at 1/500 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from 293 cells with the immunizing peptide

Anti-TIMP1 antibody - ab77847 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab77847 was used to block TIMP1 in MDA-MB-231-BM cells. Control = HAS2-expressing cells C2-4 and C4-25 = HAS2 knockdown cells

Anti-TIMP1 antibody - ab126847 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TIMP1 antibody (ab126847) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-TIMP1 antibody [102D1] - ab1827 from Abcam

Prices $384.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 102D1
ab1827 - immunohistochemistry Formalin fixed paraffin embedded human breast carcinoma stained with TIMP1, using ABC and DAB chromogen.

Anti-TIMP1 antibody [102D1] (Biotin) - ab79206 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 102D1

Anti-TIMP1 antibody [2A5] - ab2464 from Abcam

Prices $372.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 2A5

Anti-TIMP1 antibody [2E7.1] - ab28261 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E7.1
Standard curve for TIMP1 (Analyte: ab82104); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [2E7.1] to TIMP1 (ab28261) at 1µg/ml and Detector Antibody Rabbit polyclonal to TIMP1 - Carboxyterminal end (ab38978) at 0.5µg/ml.

Anti-TIMP1 antibody (Biotin) - ab77848 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP1 antibody [EP1549RY] - ab81282 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1549RY
Anti-TIMP1 antibody [EP1549RY] (ab81282) at 1/500 dilution + 5 ng of recombinant proteinSecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-TIMP1 antibody [EPR1550] - ab109125 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1550
All lanes : Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilutionLane 1 : HL60+TPA cell lysatesLane 2 : PBMC cell lysatesLysates/proteins at 10 µg per lane.

Anti-TIMP1 antibody [SPM355], prediluted - ab54442 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM355
ab54442 staining human TIMP1 in human breast carcinoma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-TIMP1 antibody - Carboxyterminal end - ab38978 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Standard curve for TIMP1 (Analyte: ab82104); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [2E7.1] to TIMP1 (ab28261) at 1µg/ml and Detector Antibody Rabbit polyclonal to TIMP1 - Carboxyterminal end (ab38978) at 0.5µg/ml.

Anti-TIMP1 antibody - Loop 1 - ab28262 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIMP1 antibody - Loop 1 (ab28262)Lane 1 : Cell media from human chondrosarcoma (no treatment).Lane 2 : Cell media from human chondrosarcoma (treated with TPA).

Anti-TIMP1 antibody - Loop 2 - ab38979 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIMP1 antibody - Loop 2 (ab38979) at 1/1000 dilutionLane 1 : Cell media from human chondrosarcoma (no treatment)Lane 2 : Cell media from human chondrosarcoma (treated with TPA)

Anti-TIMP1 antibody - Loop 3 - ab38980 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIMP1 antibody - Loop 3 (ab38980) at 1/1000 dilutionLane 1 : Human TIMP1Lane 2 : Cell media from human chondrosarcoma (untreated)Lane 3 : Cell media from human chondrosarcoma (TPA treated)

Anti-TIMP1 Antibody (clone T2) - LS-C11471 from LifeSpan Bioscience

Prices $1,015.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone T2

Anti-TIMP1 Antibody - LS-C11473 from LifeSpan Bioscience

Prices $1,080.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP1 Antibody - LS-C39717 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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