TIMP1

Gene Symbol	TIMP1
Entrez Gene	7076
Alt Symbol	CLGI, EPA, EPO, HCI, TIMP
Species	Human
Gene Type	protein-coding
Description	TIMP metallopeptidase inhibitor 1
Other Description	TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Swissprots	P01033 Q9UCU1 Q14252
Accessions	AAA75558 AAX47478 BAA01913 CAR95107 CAS92765 CBX47572 EAW59315 EAW59316 P01033 A10416 CAA00898 AK074854 BAG52016 AK296116 BAG58865 AK307222 AK310206 AK311937 BAG34878 BC000866 AAH00866 BC007097 BQ181804 BU857950 CR407638 CAG28566 CR541982 CAG46779 DQ891122 ABM82048 DQ894301 ABM85227 M12670 AAA52436 M59906 AAA63234 S68252 AAD14009 X02598 CAA26443 X03124 CAA26902 XM_005272645 XP_005272702 NM_003254 NP_003245
Function	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|P
Subcellular Location	Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
Tissue Specificity	Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TIMP1 293 Cell Lysate - 408789 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TIMP-1 Overexpression Lysate (Native) - NBL1-16924 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TIMP-1 (h): 293 Lysate - sc-110547 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TIMP1 Over-expression Lysate Product - GWB-F5F0D2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human TIMP-1 / TIMP1 HEK293 Cell Lysate (WB positive control) - 10934-HNAHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TIMP-1 / TIMP1 HEK293 Cell Lysate (WB positive control) - 10934-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TIMP-1 / TIMP1 HEK293 Cell Lysate (WB positive control) - 10934-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TIMP-1 Human Cells Transfected Lysate (positive control) (denatured) - orb173018 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

TIMP-1 Overexpression Lysate (Denatured) - H00007076-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human TIMP-1 Human Cells Transfected Lysate (positive control) (denatured) - orb173168 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human TIMP-1 Human Cells Transfected Lysate (positive control) (denatured) - orb232858 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

TIMP1-knockout Cell lysate - LC810240 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human TIMP1 Knockdown Stable Cell Line - CSC-DC015969 from Creative biogene Category Cell Line Species Human

Human TIMP1 Knockout Cell Line-HeLa - CSC-RT0537 from Creative biogene Category Cell Line Species Human

TIMP1 KO Cell Lysate-HeLa - CLKO-0042 from Creative biogene Category Cell Lysate

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