TIMP1

Gene Symbol	TIMP1
Entrez Gene	7076
Alt Symbol	CLGI, EPA, EPO, HCI, TIMP
Species	Human
Gene Type	protein-coding
Description	TIMP metallopeptidase inhibitor 1
Other Description	TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Swissprots	P01033 Q9UCU1 Q14252
Accessions	AAA75558 AAX47478 BAA01913 CAR95107 CAS92765 CBX47572 EAW59315 EAW59316 P01033 A10416 CAA00898 AK074854 BAG52016 AK296116 BAG58865 AK307222 AK310206 AK311937 BAG34878 BC000866 AAH00866 BC007097 BQ181804 BU857950 CR407638 CAG28566 CR541982 CAG46779 DQ891122 ABM82048 DQ894301 ABM85227 M12670 AAA52436 M59906 AAA63234 S68252 AAD14009 X02598 CAA26443 X03124 CAA26902 XM_005272645 XP_005272702 NM_003254 NP_003245
Function	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|P
Subcellular Location	Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
Tissue Specificity	Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIMP-1 ELISA Kit - RAB0467 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human TIMP-1 ELISA Kit - RAB0466 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

Mouse TIMP1 ELISA Kit (Sandwich ELISA) - LS-F5601 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 0.068 ng/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F5600 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 24.69-18000 pg/ml

Rat TIMP1 ELISA Kit (Sandwich ELISA) - LS-F5602 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 24.69-18000 pg/ml

Dog TIMP1 ELISA Kit (Sandwich ELISA) - LS-F6887 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 31.2 pg/ml Range 24.69-18000 pg/ml

Pig TIMP1 ELISA Kit (Sandwich ELISA) - LS-F4971 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 10.2 pg/ml Range 24.69-18000 pg/ml

Rabbit TIMP1 ELISA Kit (Sandwich ELISA) - LS-F5382 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 24.5 pg/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F195 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 24.69 pg/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F599 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 24.69-18000 pg/ml

Mouse TIMP1 ELISA Kit (Sandwich ELISA) - LS-F292 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 1.371 pg/ml Range 24.69-18000 pg/ml

Rat TIMP1 ELISA Kit (Sandwich ELISA) - LS-F321 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4 pg/ml Range 24.69-18000 pg/ml

Horse TIMP1 ELISA Kit (Sandwich ELISA) - LS-F7629 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.252 ng/ml Range 24.69-18000 pg/ml

Bovine TIMP1 ELISA Kit (Sandwich ELISA) - LS-F7832 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.92 ng/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F10061 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.434 ng/ml Range 24.69-18000 pg/ml

Mouse TIMP1 ELISA Kit (Sandwich ELISA) - LS-F10062 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.11 ng/ml Range 24.69-18000 pg/ml

Rat TIMP1 ELISA Kit (Sandwich ELISA) - LS-F10063 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 0.224 ng/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F2553 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 5 pg/ml Range 24.69-18000 pg/ml

Rat TIMP1 ELISA Kit (Sandwich ELISA) - LS-F2592 from LifeSpan Bioscience Category ELISA Kit Prices $560.00 Sizes 1 plate Sensitivity 3 pg/ml Range 24.69-18000 pg/ml

Mouse TIMP1 ELISA Kit (Sandwich ELISA) - LS-F10482 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 24.69-18000 pg/ml

Human TIMP1 ELISA Kit (Sandwich ELISA) - LS-F12762 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 24.69-18000 pg/ml

Human TIMP-1 Luminex Performance Assay - LUCB970 from R&D Systems

Human TIMP-1 Quantikine ELISA Kit - DTM100 from R&D Systems Category ELISA Kit Prices $479.00, $2,290.00, $15,560.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 0.08 ng/mL Range 0.2 - 10 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva)

Human TIMP-1 Quantikine PharmPak (50 Plates) - PDTM100 from R&D Systems Category ELISA Kit Sensitivity 0.08 ng/mL Range 0.156 - 10 ng/mL (Serum, Heparin Plasma, Saliva, Cell Culture Supernates, EDTA Plasma)

Human TIMP-1 Quantikine SixPak (6 Plates) - STM100 from R&D Systems Category ELISA Kit Sensitivity 0.08 ng/mL Range 0.156 - 10 ng/mL (Serum, Heparin Plasma, Saliva, Cell Culture Supernates, EDTA Plasma)

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