RAB31

Gene Symbol	RAB31
Entrez Gene	11031
Alt Symbol	Rab22B
Species	Human
Gene Type	protein-coding
Description	RAB31, member RAS oncogene family
Other Description	ras-related protein Rab-22B|ras-related protein Rab-31
Swissprots	Q9HC00 Q15770 B2RBT7 Q13636
Accessions	EAX01595 EAX01596 Q13636 AF183421 AAG09690 AF234995 AAG13847 AF498957 AAM21105 AI198863 AK223505 BAD97225 AK314809 BAG37334 BC001148 AAH01148 BT020027 AAV38830 BT020028 AAV38831 BU608212 BU944638 CB243279 CK005533 CN429637 CR407659 CAG28587 DA068356 DQ892578 ABM83504 DQ895794 ABM86720 U57091 AAC50773 U59877 AAB02832 NM_006868 NP_006859
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.
Subcellular Location	Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity	Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:11784320}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rab 31 (C-15) - sc-85111 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Rab 31 (S-18) - sc-85113 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-RAB31 antibody - ab89163 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-RAB31 antibody - ab103588 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB31 antibody - ab56834 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RAB31 antibody - ab116344 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAB31 Antibody (aa121-166) - LS-C313901 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB31 Antibody (C-Terminus) - LS-C145522 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAB31 Antibody (aa78-127) - LS-C186716 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

RAB31 Antibody - NBP1-79921 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

RAB31 Antibody - NBP1-80859 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAB31 Antibody (4D12) - H00011031-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4D12

RAB31 Antibody - H00011031-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

RAB31 Antibody (1C6) - H00011031-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C6

RAB31 Antibody - H00011031-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RAB31 Antibody - H00011031-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Monoclonal Anti-RAB31 antibody produced in mouse - WH0011031M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C6

Anti-RAB31 antibody produced in rabbit - HPA019717 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAB31 antibody produced in rabbit - SAB1410150 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB31 antibody produced in mouse - SAB1407093 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

RAB31 antibody - C-terminal region (ARP61983_P050) - ARP61983_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAB31 Antibody (OAAF04147) - OAAF04147 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RAB31 Polyclonal Antibody - A7506 from ABclonal Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

RAB31 antibody - 70R-19700 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

RAB31 Antibody - abx014795 from Abbexa Host Rabbit Clonality Polyclonal

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