RAB31

Gene Symbol RAB31
Entrez Gene 11031
Alt Symbol Rab22B
Species Human
Gene Type protein-coding
Description RAB31, member RAS oncogene family
Other Description ras-related protein Rab-22B|ras-related protein Rab-31
Swissprots Q9HC00 Q15770 B2RBT7 Q13636
Accessions EAX01595 EAX01596 Q13636 AF183421 AAG09690 AF234995 AAG13847 AF498957 AAM21105 AI198863 AK223505 BAD97225 AK314809 BAG37334 BC001148 AAH01148 BT020027 AAV38830 BT020028 AAV38831 BU608212 BU944638 CB243279 CK005533 CN429637 CR407659 CAG28587 DA068356 DQ892578 ABM83504 DQ895794 ABM86720 U57091 AAC50773 U59877 AAB02832 NM_006868 NP_006859
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.
Subcellular Location Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:11784320}.
Top Pathways Endocytosis

Rab 31 CRISPR/Cas9 KO Plasmid (h) - sc-417919 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 HDR Plasmid (h) - sc-417919-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 Double Nickase Plasmid (h) - sc-417919-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 Double Nickase Plasmid (h2) - sc-417919-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 CRISPR Activation Plasmid (h) - sc-417919-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 CRISPR Activation Plasmid (h2) - sc-417919-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 Lentiviral Activation Particles (h) - sc-417919-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 Lentiviral Activation Particles (h2) - sc-417919-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 31 siRNA (h) - sc-76327 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 31 shRNA Plasmid (h) - sc-76327-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 31 shRNA (h) Lentiviral Particles - sc-76327-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAB31 RNAi - H00011031-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU042611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17831 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17831 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RAB31 siRNA (Human) - CRH7538 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAB31 - MBS8228244 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RAB31 (NM_006868.3) - SHH388172 from Creative biogene

Category siRNA
Species Reactivities Human

RAB31 shRNA Plasmid (Human) - CHH7538 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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