RAB31

Gene Symbol	RAB31
Entrez Gene	11031
Alt Symbol	Rab22B
Species	Human
Gene Type	protein-coding
Description	RAB31, member RAS oncogene family
Other Description	ras-related protein Rab-22B|ras-related protein Rab-31
Swissprots	Q9HC00 Q15770 B2RBT7 Q13636
Accessions	EAX01595 EAX01596 Q13636 AF183421 AAG09690 AF234995 AAG13847 AF498957 AAM21105 AI198863 AK223505 BAD97225 AK314809 BAG37334 BC001148 AAH01148 BT020027 AAV38830 BT020028 AAV38831 BU608212 BU944638 CB243279 CK005533 CN429637 CR407659 CAG28587 DA068356 DQ892578 ABM83504 DQ895794 ABM86720 U57091 AAC50773 U59877 AAB02832 NM_006868 NP_006859
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.
Subcellular Location	Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity	Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:11784320}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RAB31 full length protein - ab90794 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Human

Human RAB31 full length protein - ab124565 from Abcam Category Protein Source E. coli Species Human

RAB31 Antibody Blocking Peptide - LS-E22634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB31 Antibody Blocking Peptide - LS-E22635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB31 Partial Recombinant Protein - H00011031-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RAB31 Recombinant Protein - H00011031-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RAB31 Protein - NBP1-99009 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

RAB31-Antibody-C-term-Blocking-Peptide - BP19029b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human RAB31 protein - orb169143 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human Rab22B (His Tag) protein - orb179623 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

RAB31 peptide - orb218391 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

RAB31 Blocking Peptide - 33R-2805 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB31 protein (His tag) - 80R-2258 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

RAB31 Blocking Peptide - abx063722 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

RAB31 / RAB22B (1-195, His-tag) - AR50342PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RAB31 / RAB22B (1-195, His-tag) - AR50342PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RAB31 / RAB22B - H00011031-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB31 / RAB22B - H00011031-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB31 / RAB22B - H00011031-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB31 / RAB22B - H00011031-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB31, 1-195aa, Human, His tag, E.coli - 01-P1518 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RAB31 fusion protein - ag7759 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RAB31 fusion protein - Ag7833 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAB31 Human - PRPS-1097 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human RAB31, Member RAS Oncogene Family Protein - BP002342-PRO-1090 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

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