SPHK2

Gene Symbol SPHK2
Entrez Gene 56848
Alt Symbol SK 2, SK-2, SPK 2, SPK-2
Species Human
Gene Type protein-coding
Description sphingosine kinase 2
Other Description sphingosine kinase type 2
Swissprots Q9BRN1 Q9NRA0 B4DU87 A0T4C8 Q9NWU7 Q9H0Q2
Accessions CBH26133 CBX51413 EAW52365 EAW52366 EAW52367 EAW52368 EAW52369 EAW52370 EAW52371 Q9NRA0 AB100373 BAC55583 AF245447 AAF74124 AK000599 BAA91280 AK074601 BAC11085 AK122735 BAG53695 AK125560 AK297787 BAH12667 AK300541 BAG62249 AL136701 CAB66636 BC006161 AAH06161 BC010671 AAH10671 BI224962 DA926908 DB053266 DB367710 DQ896790 ABM87789 EF107108 ABK81123 EU176470 ABW03921 XM_006723291 XP_006723354 XM_006723292 XP_006723355 XM_011527133 XP_011525435 XM_011527134 XP_011525436 XM_011527135 XP_011525437 NM_001204158 NP_001191087 NM_001204159 NP_001191088 NM_001204160 NP_001191089 NM_001243876 NP_001230805 NM_020126 NP_064511
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.
Subcellular Location Isoform 1: Cytoplasm. Membrane.
Top Pathways VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway

SphK2 (H-137) - sc-366378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SphK2 (H-137): sc-366378. Western blot analysis of SphK2 expression in non-transfected: sc-117750 (A) and mouse SphK2 transfected: sc-127577 (B) whole cell lysates.

SphK2 (N-19) - sc-22703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SphK2 (P-19) - sc-22704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SphK2 (P-19): sc-22704. Western blot analysis of SphK2 expression in non-transfected: sc-110760 (A) and human SphK2 transfected: sc-111125 (B) 293 whole cell lysates.

Anti-SPHK2 (phospho T614) antibody - ab111948 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111948 at 1/50 dilution staining SPHK2 in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-SPHK2 antibody - ab37977 from Abcam

Prices $400.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SPHK2 antibody (ab37977) at 1/1000 dilution + HepG2 cell Lysate at 35 µgSecondaryHRP goat anti-rabbit (H+L) at 1/5000 dilution

Anti-SPHK2 antibody - ab92607 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPHK2 antibody (ab92607) at 1/500 dilutionLane 1 : extracts from 293 cells Lane 2 : extracts from 293 cells with immunizing peptide at 10 µgLysates/proteins at 20 µg per lane.

Anti-SPHK2 antibody - ab131735 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPHK2L antibody - ab52303 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody - LS-C26940 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Western blot of endogenous sphingosine kinase 2 LF detection in Jurkat cell lysate (4 ug/lane) using X1880P (1 ug/ml) developed using anti-rabbit HRP (1:75K) and Pierce Super Signal west Femto.

Anti-SPHK2 Antibody (C-Terminus) - LS-C26797 from LifeSpan Bioscience

Prices $480.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Western blot of Sphingosine Kinase 2 antibody on 50 ng of recombinant Sphinogsine Kinase 2 enzyme. Antibody used at 1:200 dilution. Visualized using Pierce West Femto substrate system. Secondary used at 1:30k dilution. Exposure for 45 seconds.

Anti-SPHK2 Antibody (N-Terminus, AP) - LS-C245951 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (N-Terminus, APC) - LS-C245952 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (phospho-Thr614) - LS-C199598 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma, using SPHK2 (Phospho-Thr614) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-SPHK2 Antibody (N-Terminus, Biotin) - LS-C245953 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (N-Terminus, FITC) - LS-C245954 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (N-Terminus, PE) - LS-C245955 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, AP) - LS-C245956 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, Biotin) - LS-C245957 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, FITC) - LS-C245959 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, APC) - LS-C245958 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (N-Terminus, Azide-free, HRP) - LS-C247887 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, PE) - LS-C245964 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C247888 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPHK2 Antibody (aa580-629) - LS-C118372 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using SPHK2 (Ab-614) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-SPHK2 Antibody (C-Terminus) - LS-C328732 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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