| Gene Symbol |
SPHK2
|
| Entrez Gene |
56848
|
| Alt Symbol |
SK 2, SK-2, SPK 2, SPK-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine kinase 2
|
| Other Description |
sphingosine kinase type 2
|
| Swissprots |
Q9BRN1 Q9NRA0 B4DU87 A0T4C8 Q9NWU7 Q9H0Q2
|
| Accessions |
CBH26133 CBX51413 EAW52365 EAW52366 EAW52367 EAW52368 EAW52369 EAW52370 EAW52371 Q9NRA0 AB100373 BAC55583 AF245447 AAF74124 AK000599 BAA91280 AK074601 BAC11085 AK122735 BAG53695 AK125560 AK297787 BAH12667 AK300541 BAG62249 AL136701 CAB66636 BC006161 AAH06161 BC010671 AAH10671 BI224962 DA926908 DB053266 DB367710 DQ896790 ABM87789 EF107108 ABK81123 EU176470 ABW03921 XM_006723291 XP_006723354 XM_006723292 XP_006723355 XM_011527133 XP_011525435 XM_011527134 XP_011525436 XM_011527135 XP_011525437 NM_001204158 NP_001191087 NM_001204159 NP_001191088 NM_001204160 NP_001191089 NM_001243876 NP_001230805 NM_020126 NP_064511
|
| Function |
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.
|
| Subcellular Location |
Isoform 1: Cytoplasm. Membrane.
|
| Top Pathways |
VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway
|