TSC2

Gene Symbol	TSC2
Entrez Gene	7249
Alt Symbol	LAM, PPP1R160, TSC4
Species	Human
Gene Type	protein-coding
Description	tuberous sclerosis 2
Other Description	protein phosphatase 1, regulatory subunit 160|tuberin|tuberous sclerosis 2 protein
Swissprots	B7Z2B8 B4DRN2 P49815 A7E2E2 B4DIQ7 B4DIL8 O75275 Q8TAZ1 Q4LE71 C9J378
Accessions	AAB41564 AAC34210 BAA32694 EAW85556 EAW85557 EAW85558 EAW85559 EAW85560 P49815 AB210000 BAE06082 AK022401 AK094152 BAG52831 AK125096 BAG54139 AK294548 BAH11804 AK295672 BAG58530 AK295728 BAG58569 AK299343 BAG61344 BC025364 AAH25364 BC046929 AAH46929 BC150300 AAI50301 BF194994 BM966762 BX647816 CAI46010 DA316794 DB288276 KJ534954 AHW56594 KJ534955 AHW56595 KJ534956 AHW56596 KJ534957 AHW56597 KJ534958 AHW56598 KJ534982 AHW56622 KJ534983 AHW56623 KJ534984 AHW56624 KJ534985 AHW56625 KJ535011 AHW56650 KJ535022 AHW56661 KJ535038 AHW56677 KJ535039 AHW56678 KJ535051 AHW56690 KJ535091 AHW56730 KJ535094 AHW56733 S82474 AAB37376 X75621 CAA53287 XM_005255529 XP_005255586 XM_005255531 XP_005255588 XM_011522636 XP_011520938 XM_011522637 XP_011520939 XM_011522638 XP_011520940 XM_011522639 XP_011520941 XM_011522640 XP_011520942 XM_011522641 XP_011520943 NM_000548 NP_000539 NM_001077183 NP_001070651 NM_001114382 NP_001107854 NM_021055 NM_021056
Function	In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16707451}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Tissue Specificity	Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Top Pathways	p53 signaling pathway, Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Tuberin / TSC2 ELISA Kit (Cell-Based ELISA) - LS-F2369 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.6-1000 pg/ml

Mouse/Human/Rat Phospho-Tuberin / TSC2 (Ser939) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1233 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 15.6-1000 pg/ml

Laminin (LN), Human, ELISA Kit - SEA082Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 35pg/mL Range 78-5,000pg/mL

Laminin, LN, Human, ELISA Kit - E-EL-H0128 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Lipoarabinomannan, LAM, General, ELISA Kit - E1544Ge from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.312-20 ng/mL

Laminin (LN), Human, CLIA Kit - SCA082Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 29pg/mL Range 78-5000pg/mL

Human LAM ELISA Kit - HL0214 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine LAM ELISA Kit - AL0214 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Tuberin/TSC2 Colorimetric Cell-Based ELISA Kit - CB5707 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Tuberin/TSC2 (Phospho-Ser939) Colorimetric Cell-Based ELISA Kit - CBP1227 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

LAM (Lipoarabinomannan) ELISA Kit - E-EL-0027 from Elabscience Category ELISA Kit Range ~

Human Lipoarabinomannan ELISA - E01L0207 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Laminin (LN) - SEA082Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.6pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

CLIA Kit for Laminin (LN) - SCA082Hu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 2.7pg/mL. Range 6.859-5000pg/mL The standard curve concentrations used for the ELISA's were 5000pg/mL, 1666.67pg/mL, 555.56pg/mL, 185.19pg/mL, 61.728pg/mL, 20.576pg/mL, 6.859pg/mL

Human LN(Laminin) ELISA Kit - E-EL-H0128 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

LAM (Lipoarabinomannan) ELISA Kit - E-EL-0027 from Iwai North America Inc. Category ELISA Kit Prices $559.75 Sizes 1 kit Sensitivity N/A

Human IL-4 (Interleukin 4) CLIA Kit - E-CL-H0100 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Human UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) CLIA Kit - E-CL-H1383 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Tuberin/TSC2 ELISA Kit - DEIA-XYA1799 from Creative Diagnostics Category ELISA Kit

Tuberin/TSC2 (Phospho-Ser939) ELISA Kit - DEIA-XYA1800 from Creative Diagnostics Category ELISA Kit

Human LAM ELISA Kit - E022192 from Biobool Category ELISA Kit Sensitivity 0.5 ng/ml.

Human TSC2 ELISA Kit - E101430 from Biobool Category ELISA Kit

Human LAM ELISA Kit - EHL0214 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

General Lipoarabinomannan ELISA Kit - EK3775 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Sensitivity less than 0.089ng/mL Range 0.156-10 ng/mL

anti-TSC2 / Tuberin antibody - ARG56162 from Arigo Biolaboratories Category ELISA Kit

Search more