| Gene Symbol |
SLC28A3
|
| Entrez Gene |
64078
|
| Alt Symbol |
CNT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 28 (concentrative nucleoside transporter), member 3
|
| Other Description |
concentrative Na(+)-nucleoside cotransporter 3|concentrative Na+-nucleoside cotransporter|solute carrier family 28 (sodium-coupled nucleoside transporter), member 3|solute carrier family 28 member 3
|
| Swissprots |
F5GYE3 B1AML0 B4E2S8 A8K9Y4 B2RA51 Q9HAS3
|
| Accessions |
EAW62686 Q9HAS3 AA643687 AF305210 AAG22551 AK022042 AK292849 BAF85538 AK304406 BAG65240 AK310861 AK314039 BAG36748 BC093821 AAH93821 BC093823 AAH93823 DB218604 DB237216 XM_011518905 XP_011517207 XM_011518906 XP_011517208 XM_011518907 XP_011517209 XM_011518908 XP_011517210 XM_011518909 XP_011517211 XM_011518910 XP_011517212 XR_929832 NM_001199633 NP_001186562 NM_022127 NP_071410 NR_037638
|
| Function |
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. {ECO:0000269|PubMed:11032837, ECO:0000269|PubMed:16446384, ECO:0000269|PubMed:17140564}.
|
| Subcellular Location |
Isoform 1: Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart. {ECO:0000269|PubMed:11032837}.
|