SLC28A3
| Gene Symbol | SLC28A3 |
|---|---|
| Entrez Gene | 64078 |
| Alt Symbol | CNT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 28 (concentrative nucleoside transporter), member 3 |
| Other Description | concentrative Na(+)-nucleoside cotransporter 3|concentrative Na+-nucleoside cotransporter|solute carrier family 28 (sodium-coupled nucleoside transporter), member 3|solute carrier family 28 member 3 |
| Swissprots | F5GYE3 B1AML0 B4E2S8 A8K9Y4 B2RA51 Q9HAS3 |
| Accessions | EAW62686 Q9HAS3 AA643687 AF305210 AAG22551 AK022042 AK292849 BAF85538 AK304406 BAG65240 AK310861 AK314039 BAG36748 BC093821 AAH93821 BC093823 AAH93823 DB218604 DB237216 XM_011518905 XP_011517207 XM_011518906 XP_011517208 XM_011518907 XP_011517209 XM_011518908 XP_011517210 XM_011518909 XP_011517211 XM_011518910 XP_011517212 XR_929832 NM_001199633 NP_001186562 NM_022127 NP_071410 NR_037638 |
| Function | Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. {ECO:0000269|PubMed:11032837, ECO:0000269|PubMed:16446384, ECO:0000269|PubMed:17140564}. |
| Subcellular Location | Isoform 1: Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart. {ECO:0000269|PubMed:11032837}. |
CNT3 CRISPR/Cas9 KO Plasmid (h) - sc-407830 from Santa Cruz Biotechnology
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CNT3 HDR Plasmid (h) - sc-407830-HDR from Santa Cruz Biotechnology
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CNT3 Double Nickase Plasmid (h) - sc-407830-NIC from Santa Cruz Biotechnology
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CNT3 Double Nickase Plasmid (h2) - sc-407830-NIC-2 from Santa Cruz Biotechnology
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CNT3 CRISPR Activation Plasmid (h) - sc-407830-ACT from Santa Cruz Biotechnology
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CNT3 CRISPR Activation Plasmid (h2) - sc-407830-ACT-2 from Santa Cruz Biotechnology
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CNT3 Lentiviral Activation Particles (h) - sc-407830-LAC from Santa Cruz Biotechnology
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CNT3 Lentiviral Activation Particles (h2) - sc-407830-LAC-2 from Santa Cruz Biotechnology
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CNT3 siRNA (h) - sc-60425 from Santa Cruz Biotechnology
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CNT3 shRNA Plasmid (h) - sc-60425-SH from Santa Cruz Biotechnology
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CNT3 shRNA (h) Lentiviral Particles - sc-60425-V from Santa Cruz Biotechnology
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SLC28A3 RNAi - H00064078-R01 from Novus Biologicals
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MISSION® esiRNA - EHU144521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19539 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19539 from Sigma-Aldrich
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SLC28A3 siRNA (Human) - CRJ1904 from Cohesion Biosciences
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SLC28A3 - MBS8214562 from MyBioSource
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shRNA set against Human SLC28A3 (NM_022127.2) - SHH410136 from Creative biogene
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Human SLC28A3 siRNA - orb272405 from Biorbyt
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SLC28A3 shRNA Plasmid (Human) - CHJ1904 from Cohesion Biosciences
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SLC28A3 miRNA 3'UTR clone - MiUTR4H-TG08233 from Creative biogene
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