Gene Symbol | IRG1 |
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Entrez Gene | 730249 |
Alt Symbol | CAD |
Species | Human |
Gene Type | protein-coding |
Description | immunoresponsive 1 homolog (mouse) |
Other Description | aconitate decarboxylase|cis-aconitate decarboxylase|cis-aconitic acid decarboxylase|immune-responsive gene 1 protein homolog |
Swissprots | A6NK06 |
Accessions | A6NK06 EAW80560 AI652725 BX105915 DN831390 NM_001258406 NP_001245335 XM_011535210 XP_011533512 XM_011535211 XP_011533513 |
Function | Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}. |
Subcellular Location | Mitochondrion {ECO:0000250}. |
Tissue Specificity | Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}. |
IRG1 (N-20) - sc-84191 from Santa Cruz Biotechnology
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LOC730249 (C-18) - sc-84189 from Santa Cruz Biotechnology
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Anti-IRG1 antibody - ab122624 from Abcam
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Anti-IRG1 antibody - ab138627 from Abcam
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Anti-IRG1 Antibody (aa305-332, AP) - LS-C260381 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332, APC) - LS-C260383 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332, Biotin) - LS-C260385 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa306-332) - LS-C203737 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332, FITC) - LS-C260386 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332, Azide-free, HRP) - LS-C260387 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332, PE) - LS-C260388 from LifeSpan Bioscience
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Anti-IRG1 Antibody (aa305-332) - LS-C329692 from LifeSpan Bioscience
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IRG1 Antibody - NBP2-14839 from Novus Biologicals
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ANTI-IRG1 (CENTER) antibody produced in rabbit - SAB1305218 from Sigma-Aldrich
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Anti-IRG1 antibody produced in rabbit - HPA040143 from Sigma-Aldrich
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IRG1-Antibody-Center - AP18784c from Abgent, a WuXi AppTec company
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IRG1 Antibody - middle region (OAAB14322) - OAAB14322 from Aviva Systems Biology
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) - 037106 from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (AP) - 037106-AP from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (APC) - 037106-APC from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (Azide free) (HRP) - 037106-HRP from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (Biotin) - 037106-Biotin from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (FITC) - 037106-FITC from USBiological Life Science
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Anti -IRG1, ID (IRG1, Immune-responsive gene 1 protein homolog) (PE) - 037106-PE from USBiological Life Science
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ACOD1 antibody (Biotin) - orb43285 from Biorbyt
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