IRG1

Gene Symbol	IRG1
Entrez Gene	730249
Alt Symbol	CAD
Species	Human
Gene Type	protein-coding
Description	immunoresponsive 1 homolog (mouse)
Other Description	aconitate decarboxylase|cis-aconitate decarboxylase|cis-aconitic acid decarboxylase|immune-responsive gene 1 protein homolog
Swissprots	A6NK06
Accessions	A6NK06 EAW80560 AI652725 BX105915 DN831390 NM_001258406 NP_001245335 XM_011535210 XP_011533512 XM_011535211 XP_011533513
Function	Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
Subcellular Location	Mitochondrion {ECO:0000250}.
Tissue Specificity	Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

IRG1-Antibody-Center-Blocking-Peptide - BP18784c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IRG1 - IRG1-1520H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Immune-responsive gene 1 protein homolog(IRG1) - CSB-YP011825HU CSB-EP011825HU CSB-BP011825HU CSB-MP011825HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human IRG1 protein, His-tagged - IRG1-10H from Creative Biomart Category Protein Source E. coli Species Human

IRG1 Protein - NBP1-88110PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

IRG1 Peptide, Human - M34GP07746H from Creative Peptides Category Peptide Source Synthetic. Species Human

Immune-responsive gene 1 protein homolog (IRG1), Recombinant Protein - MBS1187702 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,485.00, $1,485.00, $2,070.00, $2,070.00, $2,530.00, $2,530.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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