| Gene Symbol |
IRG1
|
| Entrez Gene |
730249
|
| Alt Symbol |
CAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
immunoresponsive 1 homolog (mouse)
|
| Other Description |
aconitate decarboxylase|cis-aconitate decarboxylase|cis-aconitic acid decarboxylase|immune-responsive gene 1 protein homolog
|
| Swissprots |
A6NK06
|
| Accessions |
A6NK06 EAW80560 AI652725 BX105915 DN831390 NM_001258406 NP_001245335 XM_011535210 XP_011533512 XM_011535211 XP_011533513
|
| Function |
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
|
| Subcellular Location |
Mitochondrion {ECO:0000250}.
|
| Tissue Specificity |
Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
|