PIM2

Gene Symbol PIM2
Entrez Gene 11040
Alt Symbol -
Species Human
Gene Type protein-coding
Description Pim-2 proto-oncogene, serine/threonine kinase
Other Description pim-2 oncogene|pim-2h|proto-oncogene Pim-2 (serine threonine kinase)|serine/threonine protein kinase pim-2|serine/threonine-protein kinase pim-2
Swissprots A8K4G6 Q9P1W9 Q99739
Accessions BAA95613 CAH05302 CAH05303 CBX53832 EAW50729 EAW50730 Q9P1W9 AK290931 BAF83620 AK312745 BC018111 AAH18111 DC378253 DQ891336 ABM82262 DQ894518 ABM85444 U77735 AAC78506 XM_011543887 XP_011542189 NM_006875 NP_006866
Function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of
Tissue Specificity Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:18675992}.
Top Pathways Acute myeloid leukemia

Pim-2 (D1D2) Rabbit mAb - 4730 from Cell Signaling Technology

Prices $99.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1D2
Western blot analysis of extracts from K-562, Raji and KARPAS-620 cell lines using Pim-2 (D1D2) Rabbit mAb.

Pim-2 Antibody - 4723 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant Pim-1, Pim-2 and Pim-3 kinases using Pim-2 Antibody.

Pim-2 (D-8) - sc-271844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pim-2 (D-8): sc-271844. Western blot analysis of Pim-2 expression in non-transfected: sc-117752 (A) and human Pim-2 transfected: sc-111264 (B) 293T whole cell lysates.

Pim-2 (C-20) - sc-13675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pim-2 (C-20): sc-13675. Western blot analysis of Pim-2 expression in non-transfected: sc-110760 (A) and human Pim-2 transfected: sc-113219 (B) 293 whole cell lysates.

Pim-2 (1D12) - sc-13514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pim-2 (1D12): sc-13514. Immunofluorescence staining of methanol-fixed CTLL-2 cells showing membrane staining.

Pim-2 (E-17) - sc-26403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Pim-2 (E-20) - sc-13674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pim-2 (E-20): sc-13674. Western blot analysis of Pim-2 expression in non-transfected: sc-117752 (A) and human Pim-2 transfected: sc-111264 (B) 293T whole cell lysates.

Pim-2 (F-11) - sc-137049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pim-2 (F-11): sc-137049. Western blot analysis of Pim-2 expression in non-transfected: sc-117752 (A) and human Pim-2 transfected: sc-111264 (B) 293T whole cell lysates.

Pim-2 (F-4) - sc-271893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pim-2 (F-4): sc-271893. Western blot analysis of Pim-2 expression in non-transfected: sc-117752 (A) and human Pim-2 transfected: sc-111264 (B) 293T whole cell lysates.

Pim-2 (H-73) - sc-28778 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pim-2 (H-73): sc-28778. Western blot analysis of Pim-2 expression in non-transfected: sc-110760 (A) and human Pim-2 transfected: sc-113219 (B) 293 whole cell lysates.

Pim-2 (K-13) - sc-26402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Pim-2 (S-13) - sc-26404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pim-2 (S-13): sc-26404. Western blot analysis of Pim-2 expression in non-transfected: sc-117752 (A) and human Pim-2 transfected: sc-111264 (B) 293T whole cell lysates.

Anti-PIM2 antibody - ab97475 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ab97475 at 1/200 dilution (1) and with Hoescht nuclear stain (2).

Anti-PIM2 antibody - ab93667 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab93667, at a 1/100 dilution, staining PIM2 in formalin fixed, paraffin embedded Human B cell lymphoma tissue by Immunohistochemistry.

Anti-PIM2 antibody - ab172652 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PIM2 antibody (ab172652) at 1 µg/mlLane 1 : PIM2-transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-PIM2 antibody - ab172661 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PIM2 antibody (ab172661) at 1 µg/mlLane 1 : PIM2 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Rabbit IgG (H+L) HRP at 1/7500 dilutiondeveloped using the ECL technique

Anti-PIM2 antibody - ab177237 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Lane 1 : Anti-PIM2 antibody (ab177237) at 0.1 µg/mlLane 2 : Anti-PIM2 antibody (ab177237) at 0.1 mg/mlLane 3 : Anti-MYC tag at 1/1000 dilutionLane 1 : HEK293 lysate (in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tagLane 2 : Mock transfected HEK193 lysateLane 3 : HEK293 lysate (in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tagLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-PIM2 antibody [CHU61B] - ab107102 from Abcam

Prices $378.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone CHU61B
ab107102, at 1/2 dilution, staining PIM2 in Human seminoma by Immunohistochemistry.

Anti-PIM2 antibody [EPR6987] - ab129057 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6987
All lanes : Anti-PIM2 antibody [EPR6987] (ab129057) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : Raji cell lysateLane 4 : HL60 cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PIM2 antibody [EPR6988] - ab129193 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6988
All lanes : Anti-PIM2 antibody [EPR6988] (ab129193) at 1/1000 dilutionLane 1 : Jurkat cell lysatesLane 2 : K562 cell lysatesLane 3 : Raji cell lysatesLane 4 : HL60 cell lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-PIM2 / Pim-2 Antibody (aa282-311, APC) - LS-C216774 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIM2 / Pim-2 Antibody (clone 8G10) - LS-C115101 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8G10
IHC of paraffin-embedded Carcinoma of thyroid tissue using anti- mouse monoclonal antibody. (Dilution 1:50).

Anti-PIM2 / Pim-2 Antibody - LS-C108421 from LifeSpan Bioscience

Prices $240.00, $360.00, $530.00
Sizes 100 µl, 500 µl, 1 ml
Host Rabbit
Clonality Polyclonal
Human, Lung carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PIM2 / Pim-2 Antibody (aa189-206) - LS-C148964 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PIM2 / Pim-2 Antibody (aa282-311, AP) - LS-C216773 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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