PIM2

Gene Symbol	PIM2
Entrez Gene	11040
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Pim-2 proto-oncogene, serine/threonine kinase
Other Description	pim-2 oncogene|pim-2h|proto-oncogene Pim-2 (serine threonine kinase)|serine/threonine protein kinase pim-2|serine/threonine-protein kinase pim-2
Swissprots	A8K4G6 Q9P1W9 Q99739
Accessions	BAA95613 CAH05302 CAH05303 CBX53832 EAW50729 EAW50730 Q9P1W9 AK290931 BAF83620 AK312745 BC018111 AAH18111 DC378253 DQ891336 ABM82262 DQ894518 ABM85444 U77735 AAC78506 XM_011543887 XP_011542189 NM_006875 NP_006866
Function	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of
Tissue Specificity	Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:18675992}.
Top Pathways	Acute myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PIM2-cDNA-Clone - DC04667 from Abgent, a WuXi AppTec company Prices $421.20 Sizes 10 µg Species Human Accession NM_006875

PIM2 - MBS1274994 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC018111

Human PIM2 Gene cDNA clone plasmid - HG11560-M from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11560-ACR from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11560-CM from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid - HG11560-UT from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11560-ACG from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11560-NY from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11560-NH from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11560-CY from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11560-CH from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11560-NF from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11560-NM from Sino Biological Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11560-CF from Sino Biological Species Human

Human PIM2 ORF clone(NM_006875.3) - CDCL185721 from Creative biogene Species Human

Human PIM2 ORF Clone (BC018111) - CDCS412965 from Creative biogene Species Human Accession Q9P1W9

Human PIM2 gene - orb92263 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human PIM2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11560-ANG from Sino Biological Species Human

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